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Basic information

CohesinDB ID: CDBP00417538

Locus: chr21-33913803-33916898

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, GSE126634, ENCSR000EGW, ENCSR000BLY, ENCSR404BPV, GSE132649, GSE105028, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, GSE165895, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE152721, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE138105, GSE130135, GSE116344, ENCSR895JMI, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR000EHX, ENCSR981FDC, ENCSR767DFK, GSE62063, GSE38395, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE131956, GSE110061, GSE129526, GSE111913, GSE155324, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE38411

Cell type: RH4, GM10847, GM2610, SLK, GM19240, OCI-AML-3, HSPC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, RT-112, GM19193, HAP1, GM19099, Macrophage, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, T-47D, HEK293T, Hep-G2, Neurons-H1, A-549, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 32% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.389

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "2_TssAFlnk": 26%, "1_TssA": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOXA1, RXRB, MLL4, KDM3A, HDGF, MEN1, THAP1, ZBTB44, PAX5, ZNF320, SFPQ, TEAD1, SNAPC1, OCA2, MED26, PITX3, ZNF561, ARID5B, E4F1, SOX5, DEK, E2F4, ZNF528, RFX3, GATAD2A, NANOG, POU5F1, ZNF263, BRD3, CTBP1, ZMYND11, STAT1, SAP130, ERG, ZBTB21, EZH1, SMARCA4, FOXK2, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, DDX21, GABPB1, ZHX2, ELF4, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, NR2C2, HCFC1, RELB, EP400, RUNX1, HDAC1, CEBPA, NKX2-2, TET2, TBX3, SP5, SMARCC1, PRDM10, ZBTB2, TFDP1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, TERF1, PIAS1, SMAD1, C11orf30, EVI1, GSPT2, IKZF5, ARID2, AFF1, MBD2, ELL2, NFATC3, MEF2B, ZNF207, CREM, CHD2, NFATC1, PAF1, ZSCAN16, WT1, CREB3L1, DEAF1, JUNB, NEUROD1, BATF, KLF4, BCL11B, ZNF281, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, FOSL1, ZNF660, XBP1, KDM4B, PBX2, ATF3, ZFP64, RUNX3, CBFB, MITF, ZNF467, INTS11, JMJD1C, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, CTCF, TAF3, JUN, ZBTB20, LMO1, MNT, DPF2, SIX5, IRF4, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZBTB17, ZBTB48, ZSCAN21, NONO, SRF, NBN, KDM4A, ZNF2, HOMEZ, FOXP2, RXRA, NKX3-1, MIER3, TERF2, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, NFIL3, THAP11, SOX13, AFF4, POU4F2, ZMIZ1, SP3, ARNT, BACH1, DAXX, ZNF48, PRDM9, ZEB2, NFYA, ETV6, MAFB, ZNF10, HMGXB4, TEAD3, ZXDB, TAF7, TBX5, USF1, SP1, BCL11A, TFAP2A, ZNF479, ATF7, ASH2L, SMC3, MLLT1, STAG1, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, TP53, NFKB1, ZSCAN22, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, RNF2, BRD4, JUND, CUX1, ZFP42, PGR, SOX2, PATZ1, UBTF, TFAP4, SIN3B, CHD7, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, ZNF524, SND1, KLF1, ZNF695, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HOXC5, SMARCC2, ETS1, MYC, ZNF671, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, INO80, DNMT3B, SRSF3, EZH2, PHF8, SPI1, PCBP1, HDAC2, INTS13, RBP2, TAF9B, ZNF76, NCOA2, NFYB, ZNF554, ETV5, BCL6, SIN3A, ERG3, RARA, CREBBP, NFYC, ZNF384, TAF15, ZNF35, SMAD4, ZNF518A, CDK8, CSNK2A1, ZEB1, SREBF2, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF574, YY2, RELA, TARDBP, SKIL, ZNF611, MAX, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, AR, KMT2D, YAP1, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, HMG20A, MEIS2, SUZ12, RBFOX2, ZFHX2, NFIC, CTCFL, KLF14, MECOM, CDX2, ZNF629, ZNF506, KLF5, BCLAF1, TRIM28, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, RUNX1T1, ID3, MLLT3, GATAD1, GMEB2, ARID3A, ZNF300, MIER1, RAD21, GRHL3, PROX1, APC, ZNF614, XRCC5, NFE2, ZNF639, ARNTL, TFE3, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, MYF5, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, IRF2, NOTCH1, RUNX2, CDK6, GATA4, ZNF184, PBX4, NRF1, NR2C1, FOS, SUPT5H, CHD1, TGIF2, MED1, KDM6B, CEBPD, MYB, SCRT2, L3MBTL2, HIF2A, KLF16, NIPBL, PHF20, ZBTB7A, POU2F3, PHIP, TCF3, SKI, NELFA, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, GATA1, CEBPG, SP7, NCOA3, NR2F2, BHLHE40, NFKBIZ, TAF1, ZBTB40, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): RCAN1,RUNX1,AP000295.1,IFNAR2,ATP5PO,SLC5A3,SON,AP000311.1,MRPS6,ITSN1,CRYZL1,SMIM11A,DONSON

Function elements

Human SNPs: Urate_levels

Number of somatic mutations (coding): 67

Number of somatic mutations (non-coding): 35

Related genes and loops

Related gene: ENSG00000249624, ENSG00000159110, ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205758, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000205670, ENSG00000159200, ENSG00000159216,

Tools:

Assay

refGene

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Ruler

Cohesin site CDBP00417538

CDBP00417538 regulated genes

Related cohesin loop

Deatailed information for cohesin site CDBP00417538

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