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Basic information

CohesinDB ID: CDBP00417542

Locus: chr21-33930752-33933186

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE103477, GSE111537, GSE25021, GSE131606, ENCSR917QNE, ENCSR000DZP, GSE143937, GSE67783, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE120943, GSE116344, GSE98367, ENCSR879KXD, GSE206145, ENCSR000ECE, GSE97394, GSE55407, ENCSR167MTG, ENCSR000HPG, GSE111913, ENCSR153HNT, GSE83726, GSE50893, GSE126755, GSE38411

Cell type: MDM, RH4, OCI-AML-3, Liver, RPE, GM2630, Fibroblast, IMR-90, BCBL-1, K-562, GM18486, DKO, H1-hESC, GM18951, SNYDER, Monocytes, GM18505, GM12878, GM12891, GM2588, RT-112, GM19193, THP-1, Macrophage, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, Hep-G2, HCAEC, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 15% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.633

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 28%, "1_TssA": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, SOX2, XBP1, PATZ1, FOXA1, SUZ12, RBFOX2, RING1B, ZNF28, MLL4, HDGF, ATF3, ZBTB44, RUNX3, CHD7, ATF4, MORC2, SMARCE1, TP63, INTS11, MAF, JMJD1C, ELF1, TRIM28, ZNF121, KLF6, SMAD5, SAP30, MLL, OCA2, ZNF561, CTCF, TCF12, BAF155, E4F1, DPF2, RYBP, E2F6, IRF4, SOX6, RAD51, SMC1, TEAD4, KMT2B, ZNF175, GTF2F1, EED, POU2F2, CHD8, BRD1, POU5F1, BRD3, CDK7, ID3, KDM4C, TOP2A, ZNF263, ZBTB17, ZBTB48, ZSCAN5A, STAT1, ZNF317, CTBP1, SP4, TBP, HOXC5, ERG, ETS1, MYC, SMARCA4, RAD21, GRHL3, RXRA, FOXK2, GABPA, STAT3, IKZF1, RCOR1, TERF2, NR2F6, NFRKB, VDR, NR3C1, CEBPB, ESRRA, STAT5B, KMT2A, CREB1, EZH2, FEZF1, GABPB1, PHF8, ZKSCAN5, ELF4, SPI1, EHF, IRF1, HDAC2, INTS13, GATA2, ZNF644, FLI1, NR2C2, RELB, ZNF554, ATF1, RUNX1, ZNF585A, SMC1A, BCL6, HDAC1, CEBPA, SIN3A, SOX13, ZFX, PRDM10, RARA, IRF2, NOTCH1, ZNF384, CREBBP, BRD9, RUNX2, CDK6, OSR2, ZNF184, ARNT, DAXX, HMGB2, ZEB2, HMBOX1, SUPT5H, CDK8, CHD1, MED1, TEAD3, PML, TERF1, MYB, PIAS1, TAF7, L3MBTL2, SETDB1, SP1, BCL11A, NIPBL, HNF4A, REST, ZBTB7A, ASH2L, HNRNPLL, PHIP, TCF3, FOXP1, SMC3, MLLT1, ZNF207, MTA3, EBF1, RBBP5, CREM, ZSCAN16, GTF2B, ZNF30, WT1, MEF2C, HOXB13, ZNF580, KDM1A, YY1, RELA, TARDBP, ZNF148, HIF1A, SKIL, GATA3, TAL1, MAX, SPIB, ZNF143, GATA1, KLF4, BCL11B, CEBPG, GFI1B, NR2F2, ZNF512, NR2F1, ZNF768, KDM5B, TP53, ZBTB6, ZNF334, BRD2, ELF3, TBX21, BHLHE40, AR, TAF1, ZBTB40, EGLN2, ZBTB26, HSF1, IKZF2, JUND, ILF3, BRD4, RNF2, NOTCH3, IRF9, ZNF24, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): SLC5A3,MRPS6,RCAN1,AP000311.1,SMIM11A

Function elements

Human SNPs: Hematocrit

Number of somatic mutations (coding): 11

Number of somatic mutations (non-coding): 7

Related genes and loops

Related gene: ENSG00000249209, ENSG00000243927, ENSG00000198743, ENSG00000205670, ENSG00000159200,

eachgene

Deatailed information for cohesin site CDBP00417542