- Basic information
- CohesinDB ID: CDBP00417547
- Locus: chr21-33938778-33939105
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Data sourse: GSE206145-NatGen2015, GSE67783
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Cell type: Fibroblast, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: SA1,Rad21,SA2
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 52%,
"5_TxWk": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NME2, TFAP4, HDGF, RUNX3, PRDM1, MAF, JMJD1C, TEAD1, TRIM28, BCLAF1, ZNF217, ESR1, MED26, TCF12, LMO1, DPF2, IRF4, ZNF528, TEAD4, TFAP2C, EED, ZSCAN5D, BRD3, POU5F1, CDK7, MTA2, STAT1, SRF, DDX5, ERG, ZNF341, MYC, SMARCA4, RAD21, NKX2-1, GABPA, XRCC5, IKZF1, RCOR1, NR3C1, CEBPB, KMT2A, CREB1, EZH2, GABPB1, SPI1, HDAC2, SMARCA5, RELB, RUNX1, BCL6, CBX1, SMC1A, CEBPA, ZFX, ZNF534, ZNF18, ZNF384, NOTCH1, PBX3, FOXM1, CDK8, MYB, ZMYM3, SMAD1, EVI1, USF1, BCL11A, SP1, RBM25, ATF7, BCOR, TCF3, SMC3, MLLT1, ZNF283, FOXA2, EBF1, CREM, ZNF30, MEF2C, ZBTB33, CDK9, ZKSCAN1, KDM1A, RELA, NEUROD1, JUNB, SKIL, GATA3, BATF, TAL1, MAX, SPIB, KLF4, TCF7L2, ZNF334, BRD2, TBX21, AR, TAF1, ZBTB40, BRD4, ZNF24, ADNP
- Target gene symbol (double-evidenced CRMs): SLC5A3,MRPS6,RCAN1,SMIM11A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 1
- Related genes and loops
- Related gene:
ENSG00000243927,
ENSG00000198743,
ENSG00000205670,
ENSG00000159200,
- Related loop:
chr21:33925000-33950000~~chr21:34050000-34075000,
chr21:33925000-33950000~~chr21:34075000-34100000,
chr21:33925000-33950000~~chr21:34200000-34225000,
chr21:33925000-33950000~~chr21:34225000-34250000,
chr21:33925000-33950000~~chr21:34325000-34350000,
chr21:33925000-33950000~~chr21:34350000-34375000,
chr21:33925000-33950000~~chr21:34600000-34625000,
chr21:33925000-33950000~~chr21:35925000-35950000,