- Basic information
- CohesinDB ID: CDBP00417548
- Locus: chr21-33939669-33941762
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Data sourse: GSE67783, GSE86191, GSE98367, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE130135, GSE165895
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Cell type: RPE, Fibroblast, HCT-116, HEK293T, K-562, HSPC, Macrophage, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 38%,
"5_TxWk": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, FOXA1, PBX2, ZC3H8, HNRNPUL1, MECOM, BACH2, JMJD1C, MAF, TRIM28, JUN, TCF12, CTCF, MNT, E2F6, TRIM24, E2F1, FOXA3, EED, CHD8, BRD1, ZSCAN5D, MYCN, BRD3, TOP2A, RUNX1T1, ZSCAN5A, STAT1, ARID3A, TBP, MYC, SMARCA4, RAD21, GRHL3, IKZF1, NR3C1, CEBPB, KMT2A, CREB1, SPI1, GATA2, ZNF146, FLI1, RUNX1, SMC1A, MAFG, CEBPA, EZH2phosphoT487, ZFX, SMAD3, ERG3, SMARCC1, PRDM10, RUNX2, GATA4, ZNF48, CDK8, MED1, TEAD3, ZMYM3, SUPT16H, ZNF3, C11orf30, SETDB1, EVI1, MAFK, BCL11A, ATF7, BCOR, MLLT1, FOXA2, MTA3, EBF1, GTF2B, MAFF, WT1, HOXB13, ZNF580, KDM1A, RELA, NEUROD1, HIF1A, OTX2, TAL1, MAX, SPIB, MTA1, CEBPG, NR2F2, NEUROG2, TP53, BRD2, BRD4, MAZ, ZNF24, ZNF316, FOSL2
- Target gene symbol (double-evidenced CRMs): MRPS6,SMIM11A,SLC5A3,RCAN1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 12
- Related genes and loops
- Related gene:
ENSG00000243927,
ENSG00000198743,
ENSG00000205670,
ENSG00000159200,
- Related loop:
chr21:33925000-33950000~~chr21:34050000-34075000,
chr21:33925000-33950000~~chr21:34075000-34100000,
chr21:33925000-33950000~~chr21:34200000-34225000,
chr21:33925000-33950000~~chr21:34225000-34250000,
chr21:33925000-33950000~~chr21:34325000-34350000,
chr21:33925000-33950000~~chr21:34350000-34375000,
chr21:33925000-33950000~~chr21:34600000-34625000,
chr21:33925000-33950000~~chr21:35925000-35950000,