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Basic information

CohesinDB ID: CDBP00417552

Locus: chr21-33951082-33952547

Data sourse: ENCSR000EFJ, GSE93080, ENCSR000EAC, ENCSR000DZP, GSE67783, GSE86191, GSE98367, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE103477, GSE50893

Cell type: MDM, GM2630, RPE, Fibroblast, HCT-116, GM2610, GM12878, GM2588, IMR-90, K-562, HSPC, Macrophage, B-cell

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.856

Subunit: SMC3,Rad21,SA1,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 46%, "7_Enh": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFATC3, POU2F2, SMC1A, MEF2B, ZSCAN5D, MTA3, EBF1, CREM, ZFX, ZNF534, ZSCAN16, XBP1, ZBTB48, WT1, ZSCAN5A, MAFF, RELA, HDGF, CREBBP, PBX1, ZNF384, JUNB, RUNX2, MYC, NFIC, RAD21, RUNX3, GRHL3, SKIL, BACH1, HIF1A, BATF, GABPA, TAL1, MAX, FOXM1, PAX5, ZNF143, IKZF1, NFE2, MITF, MED1, ARNTL, VDR, MAF, CEBPB, TRIM28, MYB, CREB1, BCLAF1, NFE2L2, STAG1, LMO2, ZNF687, TP53, EPAS1, C11orf30, L3MBTL2, USF2, USF1, SPI1, TBX21, BHLHE40, AR, DPF2, INTS13, GATAD2B, IRF4, RBM25, RB1, ATF7, RNF2, NOTCH3, BRD4, IKZF2, RAD51, BCOR, E2F1, SMC3, MLLT1, RBPJ, EED

Target gene symbol (double-evidenced CRMs): SLC5A3,MRPS6,RCAN1,SMIM11A,RUNX1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000243927, ENSG00000198743, ENSG00000205670, ENSG00000159200, ENSG00000159216,

eachgene

Deatailed information for cohesin site CDBP00417552