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Basic information

CohesinDB ID: CDBP00417559

Locus: chr21-33970541-33972949

Data sourse: ENCSR000BLD, GSE104888, GSE105028, GSE131606, GSE165895, GSE138405, GSE101921, GSE206145-NatGen2015, GSE138105, GSE130135, GSE98367, ENCSR193NSH, GSE206145, GSE85526, ENCSR495WGO, GSE97394, GSE105004, GSE129526, GSE111913, ENCSR153HNT, GSE68388, GSE126990

Cell type: SLK, HuCC-T1, H9-hESC, RPE, HMEC, Fibroblast, HEKn, K-562, DKO, HFFc6, H1-hESC, RT-112, Macrophage, HUES64, Hela-Kyoto, HCT-116, HEK293T, A-549, HeLa

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 13% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.778

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 43%, "7_Enh": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOSL1, PGR, SMARCA2, HMG20A, MEIS2, XBP1, HNF1A, PATZ1, FOXA1, SUZ12, RBFOX2, PBX2, RXRB, MLL4, KDM3A, HDGF, ATF3, NFIC, ZNF362, ZBTB44, PRDM1, CHD7, ATF4, ZNF273, MXD4, ZNF189, SMARCE1, DPF1, MITF, ZNF736, CDX2, ZNF629, JMJD1C, TEAD1, TRIM28, ELF1, KLF6, SNAI2, NFE2L2, KLF10, ZNF217, ESR1, HNF1B, MED26, RCOR2, MLL, USF2, ZNF561, CTCF, TCF12, ZNF507, EP300, E4F1, BAF155, KLF1, JUN, GATA6, SOX5, DPF2, PAX8, SOX4, SIX5, IRF4, RAD51, ZNF410, E2F1, ZNF528, SMC1, ZBTB24, TEAD4, FOXA3, KMT2B, GATAD2A, PDX1, TFAP2C, GTF2F1, RBPJ, EHMT2, ZNF573, NANOG, CHD8, BRD3, POU5F1, ID3, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZMYND11, STAT1, ERF, ZNF317, MLLT3, GATAD1, DDX5, SAP130, ARID3A, SP4, SRF, TBP, NBN, ERG, ZBTB21, HOXC5, HNF4G, USP7, ETS1, MYC, ONECUT1, SMARCA4, EOMES, ARID1B, HOMEZ, RAD21, EZH1, LHX2, GRHL3, PROX1, NKX2-1, FOXK2, RXRA, GABPA, STAT3, XRCC5, ZNF614, UBN1, NKX3-1, IKZF1, NFE2, RCOR1, NR2F6, MIER3, VDR, ZNF639, NR3C1, CEBPB, ARNTL, CREB1, CCAR2, EZH2, DDX21, KLF8, GABPB1, ELF4, ZHX2, SPI1, TFE3, EHF, IRF1, HDAC2, GATA2, INTS13, ZNF644, ETV1, MXD3, FLI1, HCFC1, NR2C2, ZGPAT, DRAP1, RELB, MRTFB, ZNF76, ZC3H11A, NFIL3, ATF1, ETV5, RUNX1, THAP11, SMC1A, BCL6, CEBPA, EZH2phosphoT487, HDAC1, CRY1, ZNF335, ZFX, SOX13, ZNF534, SIN3A, SMAD3, NKX2-2, ZNF770, TRIM22, TWIST1, SMARCC1, PRDM10, RARA, ZNF384, NFYC, NOTCH1, HMBOX1, PRPF4, RUNX2, GATA4, OSR2, ZNF184, DAXX, ARNT, PBX4, ZNF48, HMGB2, ZNF518A, SMAD4, ZEB2, PBX3, NFYA, NR2C1, FOS, HMGXB4, CDK8, FOXM1, MED1, TEAD3, DIDO1, ZXDB, CEBPD, MYB, ZEB1, NR1H2, KLF9, L3MBTL2, TBX5, ZNF22, USF1, NIPBL, MAFK, SP1, HNF4A, BCL11A, IKZF5, REST, ARID1A, ATF7, ASH2L, PHIP, AFF1, MBD2, FOXP1, PRDM6, SMC3, MLLT1, STAG1, STAG2, ZNF394, ZNF283, CBFA2T2, FOXA2, MTA3, CREM, MEIS1, CBX3, EBF1, MIER2, ZNF692, GTF2B, WT1, ZSCAN16, ZNF574, DUX4, ZBTB33, CDK9, YY2, ZNF580, BCL3, HOXB13, KDM1A, YY1, RELA, CREB3L1, TARDBP, NEUROD1, JUNB, BRCA1, TCF4, HIF1A, OTX2, GATA3, TAL1, MAX, GATA1, ZNF143, MTA1, PLAG1, KLF4, ZNF592, SP7, NCOA3, GFI1B, NR2F2, ZFP69B, NR2F1, NEUROG2, TP53, PKNOX1, ZNF687, ZNF334, MYOD1, T, BRD2, ELF3, KAT8, ARID4B, AR, NFKBIZ, BHLHE40, TAF1, ZBTB40, RXR, ZNF324, RB1, ZBTB26, RNF2, NCOR1, BRD4, JUND, ILF3, CUX1, MAZ, ZSCAN23, IRF9, ZNF24, DMAP1, FOSL2

Target gene symbol (double-evidenced CRMs): RCAN1,MRPS6,RUNX1,SMIM11A,SLC5A3

Function elements

Human SNPs: Blood_urea_nitrogen_levels

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 13

Related genes and loops

Related gene: ENSG00000243927, ENSG00000198743, ENSG00000205670, ENSG00000159200, ENSG00000159216,

eachgene

Deatailed information for cohesin site CDBP00417559