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Basic information

CohesinDB ID: CDBP00417560

Locus: chr21-33973187-33974166

Data sourse: GSE98367, GSE206145, GSE206145-NatGen2015, GSE120943, ENCSR153HNT, GSE165895

Cell type: RPE, Fibroblast, Monocytes, K-562, Macrophage, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 90% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 55%, "15_Quies": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, RXRB, MLL4, HDGF, ZBTB44, IKZF3, PAX5, ZNF320, TEAD1, LMO2, OCA2, MED26, HDAC8, ZNF561, E4F1, SOX5, PYGO2, PAX8, E2F4, ZNF528, KLF3, KMT2B, GATAD2A, NANOG, BRD3, ZNF263, TOP2A, POU5F1, CTBP1, STAT1, SAP130, ERG, ZBTB21, PAX6, NFKB2, ZBTB8A, SMARCA4, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, NFRKB, CD74, CEBPB, CREB1, EPAS1, GABPB1, ZHX2, ELF4, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, HCFC1, NR2C2, MXI1, DRAP1, RELB, EP400, RUNX1, CEBPA, HDAC1, REPIN1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, SOX11, ZBTB10, ATF2, SNIP1, FOXM1, SMARCB1, ZNF584, GMEB1, TERF1, PML, SMAD1, EVI1, STAT5A, IKZF5, ARID2, OVOL3, RBM25, AFF1, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, NFATC1, SS18, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, ZFP36, TCF4, BATF, SPIB, PLAG1, ZFP69B, KLF4, BCL11B, ZKSCAN8, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, FOSL1, ZNF660, XBP1, HNF1A, KDM4B, PBX2, HNRNPK, ATF3, ZFP64, RUNX3, CBFB, ZSCAN4, TP63, MITF, BACH2, ZNF467, MAF, JMJD1C, INTS11, ELF1, MYOG, SNAI2, KLF10, SMAD5, CTCF, JUN, LMO1, MNT, ZBTB20, DPF2, IRF4, DDX20, ZNF350, RBPJ, TFAP2C, ZNF239, ZSCAN21, ZBTB17, ZNF317, ZBTB48, MTA2, SRF, NBN, CHD4, ZNF2, TSHZ1, HOMEZ, FOXP2, LHX2, RXRA, BATF3, MIER3, TERF2, LEF1, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, FOXK1, TBL1XR1, KLF8, GRHL2, ZKSCAN5, ZNF146, SMARCA5, THAP11, SOX13, AFF4, ZNF770, ZMIZ1, ZNF18, SP3, ARNT, DAXX, BACH1, ZNF48, PRDM9, HMBOX1, ZEB2, ETV6, PBX3, ZNF10, HMGXB4, TEAD3, ZXDB, ZNF680, U2AF1, KLF9, TBX5, USF1, BCL11A, SP1, NKX2-5, ZNF479, ATF7, ASH2L, PRDM6, ZNF623, SMC3, STAG2, MLLT1, STAG1, ZNF394, MTA3, EBF1, MEIS1, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, GATA3, TAL1, NRIP1, ZNF143, MTA1, TP53, NFKB1, BRD2, KAT8, TBX21, EGR1, RB1, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, IRF9, PGR, PATZ1, TFAP4, CHD7, ATF4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ESR1, TP73, SND1, KLF1, SOX4, E2F6, TRIM24, ZNF92, GTF2F1, GLIS1, POU2F2, ZNF778, ZSCAN5A, ERG2, SP4, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, EZH2, PHF8, SPI1, HDAC2, INTS13, GATAD2B, ZNF490, ZNF76, ZNF554, ETV5, BCL6, SIN3A, ERG3, MEF2A, RARA, ZNF35, CREBBP, ZNF518A, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, NCOA1, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, HOXA9, BCOR, FOXP1, NCOR2, ZNF34, ILK, PTTG1, PPARG, HDAC6, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, PKNOX1, MYOD1, T, AR, YAP1, ZNF324, RBAK, ZNF280D, DMAP1, AHR, FOSL2, ZNF391, HMG20A, ZSCAN5C, E2F7, MEIS2, RBFOX2, ZFHX2, LYL1, INSM2, NFIC, PRDM1, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, MLL, ZFP91, TCF12, BAF155, EP300, GATA6, PRDM4, CREB3, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, MYCN, RUNX1T1, ID3, CDK7, GATAD1, ARID3A, MIER1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, ZNF595, NFE2, ZNF639, FEZF1, TRPS1, ZNF664, EHF, HBP1, IRF1, TFE3, ZGPAT, MRTFB, ATF1, SMC1A, ZNF335, ZFX, FIP1L1, SMAD3, PCBP2, TWIST1, PRPF4, NOTCH1, BRD9, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, PBX4, NRF1, NR2C1, FOS, CHD1, SUPT5H, MED1, ZNF558, MYB, SCRT2, CEBPD, VEZF1, ZNF3, L3MBTL2, HIF2A, NIPBL, PHF20, ZBTB7A, GLI2, POU2F3, PHIP, TCF3, SKI, ZNF283, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, ASXL1, HIF1A, OTX2, ZNF449, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF687, ZNF213, ZNF843, BHLHE40, PTRF, TAF1, ZBTB40, ZBTB42, MYNN, NOTCH3, MAZ, MEF2D, ZNF24

Target gene symbol (double-evidenced CRMs): SLC5A3,RUNX1,SMIM11A,MRPS6,RCAN1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000243927, ENSG00000198743, ENSG00000205670, ENSG00000159200, ENSG00000159216,

eachgene

Deatailed information for cohesin site CDBP00417560