- Basic information
- CohesinDB ID: CDBP00417569
- Locus: chr21-33992885-33995165
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Data sourse: GSE67783, GSE86191, GSE98367, ENCSR879KXD, GSE101921, GSE120943, ENCSR153HNT, GSE103477, GSE55407
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Cell type: HCT-116, Monocytes, THP-1, HCAEC, K-562, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: non-Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
90% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 61%,
"7_Enh": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, ZSCAN5C, XBP1, FOXA1, MLL4, HDGF, ZNF90, ZFP64, CHD7, ZNF322, MECOM, ZNF467, JMJD1C, KLF5, ELF1, TRIM28, ZNF217, ESR1, MLL, LMO2, CTCF, TCF12, EP300, SOX5, GATA6, DPF2, PAX8, TRIM24, CREB3, ZNF674, SMC1, TEAD4, POU2F2, TFAP2C, RBPJ, EED, NANOG, CHD8, BRD1, ZSCAN5D, ZNF263, MYCN, BRD3, ID3, RUNX1T1, CTBP1, KDM4C, DUX4, ZBTB48, STAT1, MLLT3, ERG2, ERG, ETS1, MYC, EZH1, SMARCA4, EOMES, ARID1B, RAD21, GRHL3, GABPA, STAT3, XRCC5, ZNF398, IKZF1, RCOR1, NFE2, VDR, NR3C1, CEBPB, KMT2A, CREB1, SPI1, HDAC2, GATA2, INTS13, ZNF644, MXD3, FLI1, HCFC1, ZIM3, NFYB, RUNX1, THAP11, BCL6, SMC1A, CEBPA, SOX13, ZFX, ZNF770, ERG3, SP5, CREBBP, NFYC, RUNX2, CDK6, ARNT, SMAD4, ZEB2, NFYA, CDK8, MED1, TEAD3, MYB, ZMYM3, ZNF3, L3MBTL2, SETDB1, EVI1, NIPBL, BCL11A, HNF4A, NR4A1, ZBTB7A, BCOR, TCF3, SMC3, STAG1, STAG2, SKI, MEF2B, MTA3, EBF1, GTF2B, WT1, ZBTB33, HOXB13, KDM1A, YY1, RELA, ZNF148, ZFP36, HIF1A, OTX2, TAL1, MAX, SPIB, ZNF143, GATA1, TLE3, ZNF592, TP53, BCL6B, BRD2, BHLHE40, AR, ZBTB16, RXR, EGLN2, ZBTB26, HSF1, IKZF2, BRD4, NOTCH3, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): RCAN1,MRPS6,AP000311.1,ITSN1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 12
- Related genes and loops