Deatailed information for cohesin site CDBP00417580

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  • Basic information
  • CohesinDB ID: CDBP00417580
  • Locus: chr21-34017007-34023827
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, GSE105028, GSE103477, GSE111537, GSE25021, ENCSR000EDW, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE138405, GSE76893, GSE206145-NatGen2015, GSE120943, GSE112028, GSE130135, ENCSR703TNG, GSE116344, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, GSE62063, ENCSR000BMY, GSE55407, ENCSR000BTQ, GSE105004, ENCSR167MTG, GSE111913, GSE155324, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893
  • Cell type: MDM, RH4, GM10847, GM2610, GM19240, HSPC, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, GM12890, GM2255, K-562, GM18486, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Lymphoblast, GM12878, GM12891, GM2588, GM19239, HeLa-Tet-On, GM19193, RT-112, THP-1, GM19099, Macrophage, MCF-7, GM12892, Ramos, Hela-Kyoto, HEK293T, Hep-G2, GM19238, HeLa, OCI-AML-3, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 22% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.522
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: False Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 91% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 38%, "7_Enh": 32%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, CBX5, PGR, SMARCA2, HMG20A, SOX2, NME2, MEIS2, XBP1, FOXA1, PBX2, RXRB, MLL4, ZFHX2, HDGF, TSC22D4, LYL1, ATF3, THRB, NFIC, RUNX3, CHD7, IKZF3, PRDM1, ZNF207, ATF4, CBFB, MECOM, SMARCE1, PAX5, MITF, ZNF736, BACH2, HDAC3, MYOG, JMJD1C, KLF5, TEAD1, TRIM28, BCLAF1, ELF1, ZNF557, ETV1, ZNF217, RCOR2, ESR1, OCA2, MLL, LMO2, USF2, CTCF, TCF12, SND1, EP300, JUN, BAF155, ZNF157, SOX5, GATA6, DPF2, E2F6, TRIM24, IRF4, SOX6, CREB3, RAD51, ZNF528, TEAD4, FOXA3, KMT2B, GTF2F1, GATAD2A, RBPJ, EED, TFAP2C, POU2F2, CHD8, NANOG, ZSCAN5D, MYCN, POU5F1, TOP2A, ID3, BRD3, CTBP1, MTA2, RUNX1T1, ZNF317, ZSCAN5A, STAT1, SRF, SAP130, NBN, ARID3A, ERG2, HNF4G, ERG, HOXC5, CHD4, PBX1, ZNF341, ETS1, MYC, NFKB2, SMARCA4, ARID1B, RAD21, RXRA, NKX2-1, PROX1, BATF3, GABPA, FOXK2, STAT3, ZNF614, APC, XRCC5, NKX3-1, IKZF1, RCOR1, TERF2, NR2F6, NFE2, VDR, DACH1, NR3C1, CEBPB, ESRRA, STAT5B, KMT2A, CREB1, CCAR2, EZH2, FEZF1, ZNF652, MRTFA, SPI1, MIXL1, IRF1, HDAC2, GATA2, INTS13, ZNF644, GATAD2B, FLI1, HCFC1, ZGPAT, SMARCA5, RELB, MRTFB, NCOA2, MYF5, ATF1, PTBP1, RUNX1, SMC1A, CBX1, CEBPA, BCL6, EZH2phosphoT487, CRY1, SOX13, ZFX, POU4F2, MTA3, HDAC1, SMAD3, NKX2-2, FIP1L1, ZNF534, ZNF770, ERG3, TRIM22, SMARCC1, PRDM10, CEBPZ, MEF2A, RARA, CREBBP, NOTCH1, ZBTB2, ZNF384, RUNX2, CDK6, GATA4, ARNT, BACH1, DAXX, PBX4, NFIB, ZNF48, ATF2, ZEB2, SMAD4, PRDM9, ETV6, FOXM1, PBX3, FOS, CDK8, HMBOX1, MED1, CSNK2A1, GMEB1, TEAD3, TERF1, ZNF264, MYB, ZNF680, ZMYM3, PIAS1, ZNF331, ZNF3, SMAD1, SPDEF, KLF9, L3MBTL2, SETDB1, EVI1, STAT5A, MAFK, BCL11A, NIPBL, SP1, HNF4A, NR4A1, REST, ARID1A, RBM25, ATF7, POU2F3, ASH2L, CTBP2, AFF1, BCOR, TCF3, FOXP1, PHIP, ZNF623, SMC3, NCOR2, MLLT1, STAG1, NFATC3, SKI, MEF2B, PPARG, CBX3, FOXA2, EBF1, CREM, HDAC6, MEIS1, NFATC1, ZSCAN16, GTF2B, E2F8, ZBED1, MEF2C, TCF7, CDK9, HOXB13, BCL3, ZNF580, KDM1A, YY1, RELA, ZNF366, TARDBP, NEUROD1, JUNB, TCF4, SKIL, HIF1A, ZIC2, OTX2, BHLHE22, GATA3, BATF, MGA, MAF1, MAX, TAL1, NRIP1, GATA1, ZNF143, SPIB, MTA1, HAND2, TLE3, KLF4, CEBPG, NCOA3, NR2F2, NEUROG2, NR2F1, TCF7L2, ZNF687, TP53, PKNOX1, MED, NFKB1, MYOD1, ZSCAN22, EGR2, ELF3, BRD2, T, TBX21, BHLHE40, AR, PAX3-FOXO1, TAF1, ZBTB16, ZBTB40, RXR, ZBTB42, EGR1, RB1, ZNF280D, HSF1, ZBTB26, IKZF2, BRD4, JUND, SCRT1, CLOCK, RNF2, MAZ, ZNF24, AHR
  • Target gene symbol (double-evidenced CRMs): AP000311.1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 37
  • Related genes and loops
  • Related gene: ENSG00000249209,
  • Related loop: chr21:33922807-33925639~~chr21:34018905-34021636, chr21:33923163-33925652~~chr21:34019312-34021390, chr21:33923273-33925677~~chr21:34018536-34021454, chr21:33947036-33950828~~chr21:34017007-34021569, chr21:33947080-33950802~~chr21:34019317-34021802, chr21:33974662-33978199~~chr21:34019317-34021802, chr21:33974892-33977435~~chr21:34017276-34018537, chr21:34018536-34021454~~chr21:34347284-34348765, chr21:34018567-34021276~~chr21:34347169-34348885, chr21:34025000-34050000~~chr21:34500000-34525000,
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