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Basic information

CohesinDB ID: CDBP00417611

Locus: chr21-34077159-34078441

Data sourse: GSE103477, ENCSR153HNT, GSE98367

Cell type: K-562, MDM, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 43%, "7_Enh": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, SFPQ, TEAD1, ZNF121, LMO2, OCA2, MED26, HDAC8, ZNF561, E4F1, SOX5, PAX8, E2F4, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, BRD3, CTBP1, STAT1, SAP130, ERG, PAX6, ZBTB8A, SMARCA4, ZNF180, UBN1, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, GATA2, MXD3, FLI1, HCFC1, MXI1, ZNF785, DRAP1, RELB, EP400, RUNX1, CEBPA, NKX2-2, HDAC1, SP5, TRIM22, SMARCC1, TFDP1, ELK1, ATF2, FOXM1, SP2, SMARCB1, PML, PIAS1, SMAD1, NR1H2, MBD1, GSPT2, IKZF5, ARID2, RBM25, MBD2, ELL2, HMGB1, NFATC3, MEF2B, CBX3, ZNF207, CREM, CHD2, SS18, NFATC1, PAF1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, BATF, MAF1, PLAG1, KLF4, BCL11B, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZBTB26, HSF1, SCRT1, ILF3, FOSL1, ZNF660, XBP1, KDM4B, PBX2, ZNF596, HNRNPK, ATF3, ZFP64, RUNX3, CBFB, ZNF273, TP63, ZSCAN4, MITF, MAF, INTS11, JMJD1C, ELF1, RBM39, KLF10, SMAD5, FUS, JUN, CTCF, TAF3, MNT, LMO1, RYBP, DPF2, IRF4, ZNF677, RBPJ, TFAP2C, MLX, ZNF317, ZBTB17, ZBTB48, NONO, SRF, PPARGC1A, DDX5, NBN, KDM4A, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, ZBTB14, SSRP1, ZSCAN29, SMARCA5, NFIL3, THAP11, CTNNB1, EZH2phosphoT487, SOX13, AFF4, ZNF770, ZMIZ1, ZNF18, SP3, ARNT, BACH1, DAXX, ZNF48, ZEB2, NFYA, HMBOX1, PBX3, NCAPH2, MAFB, ZNF10, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, SP1, BCL11A, ZNF479, ATF7, ASH2L, CTBP2, SMC3, STAG1, STAG2, MLLT1, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, KDM1A, ZNF492, ZNF441, BRG1, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, TP53, ZNF334, NFKB1, ZSCAN22, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, JUND, BRD4, CUX1, PGR, FANCL, SOX2, PATZ1, RING1B, UBTF, LEO1, TFAP4, SIN3B, CHD7, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, KLF1, SOX4, E2F6, TRIM24, U2AF2, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ZNF671, ARID1B, ZNF24, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, INO80, DNMT3B, SRSF3, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ZNF76, ETV5, BCL6, SIN3A, ERG3, RARA, NFYC, CREBBP, ZNF384, TAF15, ZNF169, SMAD4, CBFA2T3, CDK8, CSNK2A1, ZEB1, SUPT16H, RBM22, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, JDP2, TCF7, FOXO3, RELA, TARDBP, SKIL, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, MYOD1, T, AR, ZNF324, HEXIM1, DMAP1, AHR, MBD3, FOSL2, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, ZFHX2, INSM2, NFIC, CTCFL, PRDM1, KLF14, MECOM, CDX2, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, COBLL1, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, CREB3, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, MLLT3, GATAD1, ARID3A, ASCL1, MIER1, EOMES, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, TFE3, HBP1, ZNF664, IRF1, ZGPAT, MRTFB, ATF1, PTBP1, CBX1, SMC1A, SIRT6, FIP1L1, ZFX, ZNF534, ZNF335, SMAD3, NMYC, TWIST1, NSD2, IRF2, NOTCH1, RUNX2, ZSCAN30, GATA4, CDK6, ZNF184, OSR2, SMAD2, NRF1, PBX4, CHD1, FOS, SUPT5H, TGIF2, MED1, KDM6B, MYB, CEBPD, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, CCNT2, PHIP, TCF3, ZNF783, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, SP140, HIF1A, OTX2, GATA1, CEBPG, SP7, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB40, MYNN, NOTCH3, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): MRPS6,ATP5PO,SLC5A3,ITSN1,AP000311.1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 10

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743,

eachgene

Deatailed information for cohesin site CDBP00417611