Deatailed information for cohesin site CDBP00417619

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  • Basic information
  • CohesinDB ID: CDBP00417619
  • Locus: chr21-34091155-34093003
  • Data sourse: ENCSR000BLD, ShirahigeLab-GSE177045, GSE104888, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, GSE126634, ENCSR000EGW, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE121355, GSE103477, GSE111537, GSE25021, GSE108869, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE93080, ENCSR000DZP, GSE138405, GSE152721, ENCSR198ZYJ, GSE138105, GSE130135, ENCSR703TNG, ENCSR000EEG, GSE98367, ENCSR000BLS, ENCSR000EHW, ShirahigeLab, ENCSR000ECE, ENCSR000BMY, ENCSR000EHX, ENCSR984DZW, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, ENCSR000HPG, GSE155324, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, GSE126990, GSE50893, ENCSR000ECS
  • Cell type: MDM, SLK, Liver, H9-hESC, RPE, Ishikawa, HeLa-S3, IMR-90, K-562, H1-hESC, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, THP-1, Macrophage, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, GM19238, OCI-AML-3, HAP1
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 17% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.667
  • Subunit: SA1,Rad21,SMC1,SA2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 91% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 55%, "7_Enh": 32%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOSL1, PGR, ZSCAN5C, ZNF660, SOX2, MEIS2, PATZ1, FOXA1, RBFOX2, PBX2, ZFHX2, CTCFL, IKZF3, ZNF189, MECOM, SMARCE1, MZF1, ZNF467, ZNF629, ELF1, BCLAF1, KLF6, ESR1, ZNF561, CTCF, JUN, BAF155, ZNF260, SOX5, PAX8, SOX6, SMC1, ZNF92, FOXA3, PDX1, TFAP2C, CHD8, POU5F1, ZSCAN21, ZBTB17, ZBTB48, ZSCAN5A, DUX4, NONO, SRF, ERG2, TBP, ERG, ETS1, MYC, RAD21, NKX2-1, NKX3-1, RCOR1, NFE2, ZNF639, ZNF750, KMT2A, KLF8, SPI1, IRF1, GATA2, FLI1, RUNX1, SMC1A, NKX2-2, SOX13, ZFX, SIN3A, ZNF770, ERG3, TRIM22, PRDM10, ZBTB2, ZNF384, NOTCH1, ZNF35, RUNX2, GATA4, OSR2, ZNF184, ZEB2, FOS, CDK8, ZXDB, MYB, SCRT2, ZMYM3, EVI1, RBM22, BCL11A, HNF4A, REST, ZNF479, RBM25, PHIP, FOXP1, PRDM6, SMC3, ZNF34, STAG1, FOXA2, NFATC1, PAF1, ZNF600, ZNF692, ZSCAN16, WT1, MEF2C, CDK9, HOXB13, KDM1A, RELA, NEUROD1, HIF1A, OTX2, TAL1, MAX, SPIB, GATA1, AGO2, ZNF143, KLF4, SP7, GFI1B, KDM5B, TP53, PKNOX1, EGR2, BRD2, ELF3, BHLHE40, AR, MYNN, SCRT1, BRD4, MAZ
  • Target gene symbol (double-evidenced CRMs): ATP5PO,AP000311.1,SLC5A3,MRPS6,ITSN1
  • Function elements
  • Human SNPs: Red_blood_cell_count
  • Number of somatic mutations (coding): 18
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743,
  • Related loop: chr21:33900000-33925000~~chr21:34075000-34100000, chr21:33925000-33950000~~chr21:34075000-34100000, chr21:33967731-33970173~~chr21:34092084-34093399, chr21:34075000-34100000~~chr21:34175000-34200000, chr21:34075000-34100000~~chr21:34325000-34350000,
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