- Basic information
- CohesinDB ID: CDBP00417634
- Locus: chr21-34133659-34134671
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE126634, GSE116868, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR917QNE, GSE115602, ENCSR000BTU, ENCSR000DZP, GSE143937, ENCSR000BKV, GSE138405, GSE76893, GSE101921, GSE152721, ENCSR703TNG, GSE106870, GSE145327, GSE94872, ENCSR000EEG, GSE98367, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, GSE55407, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE126990, GSE50893, GSE126755, ENCSR000ECS
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Cell type: MDM, GM10847, CVB-hiPSC, OCI-AML-3, Liver, HuCC-T1, H9-hESC, RPE, Ishikawa, HeLa-S3, K-562, GM18486, DKO, H1-hESC, MB157, GM12878, SK-N-SH, THP-1, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, HUVEC, HCAEC, GM19238, Neutrophil, HAP1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 21% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.678
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 51%,
"4_Tx": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, SMC1A, CHD8, CEBPA, MYCN, MAFG, RUNX1T1, CBX3, ZFX, PPARG, GTF2B, WT1, STAT1, SRF, MEF2C, HOXB13, ERG, RELA, AHR, CTCFL, RAD21, SP140, ZIC2, GRHL3, HIF1A, ATF2, SMC3, TAL1, MAX, XRCC5, PAX5, PRDM14, IKZF1, MITF, ZNF143, NFE2, VDR, CEBPB, TRIM28, KMT2A, NFE2L2, EZH2, TP53, MLL, ESR1, MYOD1, GABPB1, CTCF, RBM22, SPI1, NFKBIZ, PAX3-FOXO1, HDAC2, RXR, GATA2, ZNF479, BRD4, JUND, AFF1, MAZ, SMC1, TEAD4, STAG1, CC2D1A
- Target gene symbol (double-evidenced CRMs): AP000311.1,ITSN1,MRPS6
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 4
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000249209,
ENSG00000205726,
ENSG00000243927,
- Related loop:
chr21:33675000-33700000~~chr21:34125000-34150000,
chr21:33975000-34000000~~chr21:34125000-34150000,
chr21:34125000-34150000~~chr21:34225000-34250000,
chr21:34125000-34150000~~chr21:34250000-34275000,
chr21:34125000-34150000~~chr21:34325000-34350000,
chr21:34125000-34150000~~chr21:34625000-34650000,
chr21:34128276-34130379~~chr21:34200926-34203224,
chr21:34128540-34130047~~chr21:34201503-34202809,
chr21:34128593-34130330~~chr21:34201154-34203236,
chr21:34128593-34130330~~chr21:34351015-34352657,
chr21:34133133-34135105~~chr21:34242552-34244759,
chr21:34133158-34135052~~chr21:34201091-34202966,