- Basic information
- CohesinDB ID: CDBP00417641
- Locus: chr21-34147864-34149392
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Data sourse: GSE72082, GSE126634, GSE116868, GSE206145, GSE152721
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Cell type: RPE, MB157, HAP1, Hep-G2
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES,Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 37%,
"7_Enh": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, HMG20A, SOX2, FOXA1, HLF, NFIC, RUNX3, PAX5, MAF, TEAD1, TRIM28, ZNF573, RCOR2, ESR1, OCA2, CTCF, JUN, EP300, GATA6, SOX5, TEAD4, GATAD2A, CHD8, POU5F1, TOP2A, ZBTB17, ZBTB48, ZSCAN5A, ZNF300, HNF4G, MYC, SMARCA4, LHX2, XRCC5, NR3C1, CEBPB, KMT2A, ZNF652, SPI1, GATA2, ZNF644, NFIL3, BCL6, CEBPA, SOX13, ZFX, SMARCC1, MEF2A, RARA, ZNF384, RUNX2, GATA4, ARNT, SMAD4, CBFA2T3, TERF1, RBM22, BCL11A, HNF4A, BCOR, CBFA2T2, MEF2B, PPARG, FOXA2, EBF1, MEIS1, PAF1, NFATC1, FOXF1, MEF2C, HOXB13, MPHOSPH8, KDM1A, RELA, OTX2, TAL1, GATA1, ZNF143, ZFP69B, CEBPG, NR2F2, TP53, TBX21, BHLHE40, AR, HSF1, NOTCH3, BRD4, CLOCK, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): ITSN1,AP000311.1,MRPS6
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 2
- Related genes and loops
- Related gene:
ENSG00000249209,
ENSG00000205726,
ENSG00000243927,
- Related loop:
chr21:33675000-33700000~~chr21:34125000-34150000,
chr21:33675000-33700000~~chr21:34150000-34175000,
chr21:33975000-34000000~~chr21:34125000-34150000,
chr21:34125000-34150000~~chr21:34225000-34250000,
chr21:34125000-34150000~~chr21:34250000-34275000,
chr21:34125000-34150000~~chr21:34325000-34350000,
chr21:34125000-34150000~~chr21:34625000-34650000,
chr21:34150000-34175000~~chr21:34250000-34275000,
chr21:34150000-34175000~~chr21:34325000-34350000,
chr21:34150000-34175000~~chr21:34525000-34550000,
chr21:34150000-34175000~~chr21:34600000-34625000,
chr21:34150000-34175000~~chr21:34650000-34675000,
chr21:34150000-34175000~~chr21:42625000-42650000,