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Basic information

CohesinDB ID: CDBP00417662

Locus: chr21-34198106-34198720

Data sourse: GSE105028, GSE111537, ENCSR153HNT, GSE98367

Cell type: K-562, OCI-AML-3, Macrophage, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: non-Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 43%, "7_Enh": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, RXRB, MLL4, KDM3A, HDGF, THAP1, MORC2, PAX5, TEAD1, LMO2, MED26, PITX3, ZNF561, E4F1, SOX5, E2F4, ZNF410, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, BRD3, TOP2A, ZNF263, CTBP1, DUX4, STAT1, ZNF563, SAP130, ERG, ZBTB21, NFKB2, ZBTB8A, EZH1, SMARCA4, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, DACH1, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, ZNF257, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, RELB, RUNX1, CEBPA, NKX2-2, HDAC1, REPIN1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ZBTB10, SP2, GMEB1, TERF1, PIAS1, EVI1, MBD1, STAT5A, GSPT2, IKZF5, AFF1, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, WT1, MEF2C, NEUROD1, JUNB, TCF4, ZFP36, SPIB, ZNF333, PLAG1, ZFP69B, BCL11B, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, FOSL1, ZNF660, XBP1, KDM4B, PBX2, HNRNPK, THRB, ATF3, ZFP64, RUNX3, CBFB, ZSCAN4, TP63, ZNF467, JMJD1C, MAF, ELF1, RBM39, SNAI2, FUS, CTCF, JUN, TAF3, ZBTB20, MNT, DPF2, RYBP, IRF4, ZNF423, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZSCAN21, ZBTB48, ZNF317, ZBTB17, NONO, SRF, DDX5, NBN, CHD4, KDM4A, HOMEZ, ZNF2, FOXP2, RXRA, BATF3, NKX3-1, PRDM14, MIER3, HNRNPH1, LEF1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, CCAR2, KLF8, GRHL2, EBF3, ZBTB14, SSRP1, SMARCA5, NFIL3, THAP11, ZBTB24, EZH2phosphoT487, SOX13, AFF4, POU4F2, ZMIZ1, ARNT, BACH1, DAXX, ZNF48, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, HMGXB4, TEAD3, DIDO1, ZXDB, U2AF1, KLF9, TBX5, USF1, SP1, BCL11A, TFAP2A, ZNF479, ATF7, ASH2L, GLIS2, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, ZNF580, ZKSCAN1, KLF7, KDM1A, ZNF441, ZNF266, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, MTA1, AGO2, TP53, ZNF334, NFKB1, ZSCAN22, ZNF140, PHOX2B, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, JUND, BRD4, CUX1, ZSCAN23, TBX2, PGR, SOX2, PATZ1, RING1B, UBTF, TFAP4, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, SAP30, ESR1, TP73, KLF1, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, GATAD2B, ZNF490, NFYB, ZNF554, ZNF76, ETV5, BCL6, SIN3A, ZFP37, ERG3, RARA, ZNF384, NFYC, CREBBP, TAF15, ZNF35, ZNF169, HMGB2, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZMYM3, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, ZNF662, YY2, ZFP14, RELA, TARDBP, SKIL, MGA, MAX, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, ZNF791, PKNOX1, ZNF547, MYOD1, AR, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, ZNF90, INSM2, NFIC, CTCFL, PRDM1, MECOM, ZNF736, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, MLL, USF2, ZFP91, TCF12, EP300, BAF155, GATA6, PRDM4, GLI4, SOX6, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, GATAD1, ARID3A, ASCL1, USP7, ZNF341, EOMES, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, TCF25, ZNF639, ZNF667, ZNF750, FEZF1, TFE3, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, MYF5, ATF1, PTBP1, SMC1A, MAFG, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, PCBP2, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, OSR2, ZNF184, NR2C1, FOS, CHD1, TGIF2, MED1, CEBPD, MYB, KDM6B, SCRT2, ZNF558, ZNF3, L3MBTL2, KLF16, NIPBL, ZBTB7A, CCNT2, PHIP, TCF3, KLF13, FOXA2, RBBP5, ZNF600, MIER2, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, OTX2, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB40, MYNN, NOTCH3, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): MRPS6,ITSN1,AP000311.1,RCAN1,SLC5A3,ATP5PO

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000159200,

eachgene

Deatailed information for cohesin site CDBP00417662