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Basic information

CohesinDB ID: CDBP00417664

Locus: chr21-34205572-34206804

Data sourse: GSE93080, GSE98367, ENCSR000BLY, GSE206145-NatGen2015, ENCSR153HNT, ENCSR000EHX, GSE50893, GSE165895

Cell type: Fibroblast, GM2610, GM12878, GM12890, SK-N-SH, K-562, Macrophage, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 54%, "7_Enh": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, SMARCA2, SOX2, FOXA1, NFIC, CHD7, BACH2, MAF, NFE2L2, ZNF217, MLL, TCF12, BAF155, EP300, DPF2, TRIM24, IRF4, TEAD4, KMT2B, PDX1, RBPJ, GLIS1, POU2F2, MTA2, STAT1, ERG, HOXC5, CHD4, ASCL1, MYC, NKX2-1, BATF3, STAT3, NKX3-1, IKZF1, NFE2, RCOR1, CEBPB, STAT5B, CREB1, SPI1, FLI1, MRTFB, MAFG, SMC1A, NKX2-2, SMARCC1, PRDM10, TWIST1, MEF2A, ZNF384, PBX4, BACH1, PBX3, MAFB, FOS, CDK8, MED1, MYB, PIAS1, C11orf30, STAT5A, MAFK, BCL11A, POU2F3, ATF7, ASH2L, SMC3, MEF2B, FOXA2, CREM, EBF1, CHD2, ZSCAN16, MAFF, MEF2C, CDK9, RELA, JUNB, OTX2, GATA3, BATF, MAX, SPIB, NEUROG2, ELF3, AR, ZBTB42, BRD4, JUND, ZNF24, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): SLC5A3,RCAN1,AP000311.1,SON,DONSON,ITSN1,ATP5PO,MRPS6

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000159200,

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Deatailed information for cohesin site CDBP00417664