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Basic information

CohesinDB ID: CDBP00417669

Locus: chr21-34222518-34224255

Data sourse: GSE67783, GSE86191, GSE98367, GSE206145-NatGen2015, ENCSR153HNT

Cell type: Fibroblast, HCT-116, K-562, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 62%, "14_ReprPCWk": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, HMG20A, NME2, XBP1, FOXA1, RXRB, ATF3, NFIC, BMI1, CBFB, TP63, MITF, JMJD1C, TEAD1, ELF1, TRIM28, RBM39, RCOR2, OCA2, USF2, CTCF, EP300, SOX5, GATA6, TRIM24, RAD51, FOXA3, KMT2B, GATAD2A, TFAP2C, ZSCAN5D, MYCN, TOP2A, ID3, ZBTB48, STAT1, ZNF205, SAP130, ERG, OGG1, MYC, RAD21, GRHL3, RXRA, STAT3, ZNF614, XRCC5, IKZF1, MIER3, HNRNPH1, NR2F6, CEBPB, KMT2A, CCAR2, SPI1, MIXL1, HDAC2, GATA2, INTS13, ZNF644, MXD3, FLI1, ZGPAT, ZIM3, ETV5, RUNX1, BCL6, SMC1A, CEBPA, SOX13, ZFX, TET2, ERG3, CBX8, RARA, ZBTB2, RUNX2, GATA4, ARNT, ZNF48, SMAD4, CDK8, MED1, TEAD3, ZNF3, USF1, SP1, HNF4A, IKZF5, REST, AFF1, FOXP1, STAG1, CBFA2T2, PPARG, FOXA2, WT1, MEF2C, TCF7, CDK9, HOXB13, KDM1A, YY1, RELA, SP140, MAX, SPIB, GATA1, CEBPG, NR2F2, PHF5A, ARID4B, AR, PAX3-FOXO1, ZBTB16, RNF2, NCOR1, BRD4, ILF3, MAZ, AHR

Target gene symbol (double-evidenced CRMs): AP000311.1,RCAN1,ITSN1,SON,SLC5A3,DONSON,MRPS6,ATP5PO

Function elements

Human SNPs: Percentage_gas_trapping

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000159200,

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Deatailed information for cohesin site CDBP00417669