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Basic information

CohesinDB ID: CDBP00417678

Locus: chr21-34242589-34245639

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CUTLL1, CVI-hiPSC, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, A-549, HUVEC, HCAEC, GM19238, BGO3, TC-71, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 66% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.222

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 80%, "14_ReprPCWk": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOXA1, SUZ12, KDM3A, ZC3H8, CTCFL, RUNX3, IKZF3, ZNF444, TEAD1, TRIM28, NFE2L2, ESR1, USF2, CTCF, JUN, KLF1, MNT, RYBP, E2F6, IRF4, SMC1, TEAD4, ZNF175, TFAP2C, POU2F2, MYCN, ZBTB48, ZSCAN5A, SRF, SAP130, ERG, MYC, RAD21, GRHL3, RXRA, NKX2-1, XRCC5, NKX3-1, IKZF1, NFE2, NR2F6, ESRRA, CREB1, SPI1, GATA2, FLI1, SMARCA5, MRTFB, THAP11, SMC1A, BCL6, ZFX, SMAD3, ZNF654, ZNF770, TRIM22, ZBTB2, IRF2, RUNX2, PRDM9, HMGXB4, TEAD3, DIDO1, PIAS1, SMAD1, ZNF3, KLF9, USF1, BCL11A, HNF4A, IKZF5, REST, SMC3, STAG2, STAG1, FOXA2, MTA3, WT1, MEF2C, HOXB13, ZKSCAN1, YY1, RELA, ZFP36, HIF1A, MAX, ZNF143, TCF7L2, KDM5B, TP53, ARID4B, AR, ZNF579, EGLN2, RB1, HSF1, RNF2, IKZF2, BRD4

Target gene symbol (double-evidenced CRMs): RCAN1,AP000311.1,MRPS6,ATP5PO,ITSN1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000159200,

eachgene

Deatailed information for cohesin site CDBP00417678