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Basic information

CohesinDB ID: CDBP00417700

Locus: chr21-34334498-34338506

Data sourse: ENCSR000BTQ, ENCSR000BTU, ENCSR167MTG, ENCSR000EAC, GSE93080, GSE67783, ENCSR000BKV, GSE72082, GSE86191, ENCSR000HPG, ENCSR000BLY, ENCSR000BLS, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, ENCSR703TNG, GSE25021, GSE50893, GSE165895

Cell type: RPE, GM2630, Fibroblast, Ishikawa, GM12890, GM2255, IMR-90, K-562, HFFc6, SNYDER, GM12878, GM2588, SK-N-SH, GM19239, GM19193, MCF-7, GM12892, HCT-116, Hep-G2, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 12% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.778

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 65% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 33%, "7_Enh": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: BRD1, FOXA2, NKX2-2, RBPJ, SOX2, ZFX, ERG3, SMARCC1, RELA, ZBTB2, ASCL1, MCM5, SMARCA4, GATA4, MCM3, RAD21, ARNT, MAX, GATA1, PLAG1, NR3C1, KDM5B, STAG1, ESR1, LMO2, CTCF, TCF12, USF1, PAX3-FOXO1, GATA2, POU2F3, BRD4, MAZ, PDX1, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): CBR1,CRYZL1,AP000311.1,ATP5PO,ITSN1,MRPS6,URB1,RCAN1,SLC5A3,SETD4

Function elements

Human SNPs: Height

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000142207, ENSG00000249209, ENSG00000205758, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000159200, ENSG00000185917, ENSG00000159228,

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Deatailed information for cohesin site CDBP00417700