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Basic information

CohesinDB ID: CDBP00417704

Locus: chr21-34344734-34353465

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, CUTLL1, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, HeLa, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 82% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.111

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 65% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 34%, "7_Enh": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, SOX2, NME2, FOXA1, HLF, RXRB, ATF3, NFIC, ZBTB5, CHD7, ZNF736, TEAD1, TRIM28, ZNF573, ETV1, ZNF23, USF2, CTCF, TCF12, JUN, EP300, SOX5, ZNF302, ZNF528, FOXA3, TFAP2C, GLIS1, POU2F2, BRD1, ZSCAN5D, MYCN, ZNF263, TOP2A, ID3, CTBP1, ZBTB17, ZBTB48, ZSCAN5A, SAP130, ZNF300, MYC, SMARCA4, HOMEZ, RAD21, RXRA, APC, STAT3, IKZF1, RCOR1, NR3C1, CEBPB, EZH2, GRHL2, SPI1, TFE3, ZNF257, GATA2, FLI1, MXI1, MRTFB, NFIL3, ZFX, TET2, ZNF770, CBX8, SMARCC1, PRDM10, TWIST1, RARA, RUNX2, GATA4, ARNT, SMAD4, PBX3, FOS, TEAD3, ZNF3, SETDB1, SP1, IKZF5, REST, FOXP1, STAG1, TRP47, TBL1X, FOXA2, WT1, FOXF1, HOXB13, YY1, RELA, JUNB, MCM3, SP140, ZFP36, HIF1A, GATA3, ZNF519, TAL1, MAX, GATA1, ZNF143, CBX2, PLAG1, NR2F2, NEUROG2, ZNF334, MYOD1, T, ELF3, BHLHE40, AR, PAX3-FOXO1, EGLN2, HEXIM1, HSF1, RNF2, BRD4, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): CRYZL1,CFAP298-TCP10L,SON,DOP1B,MORC3,ITSN1,CBR3,URB1,MRPS6,RCAN1,AP000311.1,DONSON,CBR1,IL10RB,ATP5PO,RUNX1,SLC5A3,SETD4,AP000295.1,IFNGR2,IFNAR2

Function elements

Human SNPs: Heel_bone_mineral_density

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000142207, ENSG00000265590, ENSG00000249624, ENSG00000159110, ENSG00000243646, ENSG00000159128, ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205758, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000159200, ENSG00000159216, ENSG00000185917, ENSG00000159228, ENSG00000159231, ENSG00000142197, ENSG00000159256,

eachgene

Deatailed information for cohesin site CDBP00417704