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Basic information

CohesinDB ID: CDBP00417707

Locus: chr21-34360486-34364137

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CUTLL1, CVI-hiPSC, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 78% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.133

Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 65% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 34%, "14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, HMG20A, ZNF660, XBP1, FOXA1, HLF, RXRB, MLL4, KDM3A, TFAP4, SIN3B, ATF3, ZC3H8, ZFP64, CTCFL, RUNX3, ZNF444, CBFB, MXD4, PAX5, ZNF320, JMJD1C, MAF, TEAD1, TRIM28, BCLAF1, RBM39, KLF6, NFE2L2, LMO2, ESR1, OCA2, USF2, ZNF561, CTCF, TCF12, JUN, BAF155, ARID5B, ZNF695, LMO1, GATA6, SOX5, E2F6, IRF4, RFX5, E2F4, DEK, E2F1, ZNF528, SMC1, TEAD4, FOXA3, ZNF175, KMT2B, GTF2F1, GATAD2A, RBPJ, EED, TFAP2C, EHMT2, POU2F2, CHD8, BRD3, MYCN, RUNX1T1, POU5F1, CDK7, ZSCAN21, ZBTB17, ZBTB48, ZNF317, STAT1, SRF, GATAD1, SAP130, MLLT3, ARID3A, SP4, TBP, ERG, HOXC5, ASCL1, MYC, EZH1, ZNF2, HOMEZ, RAD21, PROX1, NKX2-1, GABPA, STAT3, XRCC5, ZNF614, NKX3-1, MIER3, NFE2, RCOR1, NR3C1, ESRRA, ZNF85, CEBPB, STAT5B, CREB1, ZBTB11, EZH2, JMJD6, FEZF1, ZHX2, SPI1, MIXL1, TFE3, HBP1, KLF17, HDAC2, GATA2, ZNF182, ZNF644, FLI1, DRAP1, ZGPAT, MXI1, SMARCA5, RELB, MRTFB, NFIL3, ZNF554, ATF1, ETV5, RUNX1, THAP11, SMC1A, BCL6, HDAC1, NKX2-2, ATF2, CBX1, SIN3A, ZFX, SOX13, AFF4, CEBPA, SMAD3, ZNF654, ZNF770, TRIM22, ZNF18, PRDM10, SMARCC1, ZBTB2, CBX4, NOTCH1, ZNF35, RARA, CREBBP, RUNX2, CDK6, GATA4, ZNF184, PBX4, ARNT, TFDP1, HMGB2, ZNF48, ZEB2, ZNF518A, HMBOX1, CBFA2T3, SMAD4, NFYA, FOS, CDK8, HMGXB4, MAFB, MED1, ICE2, TEAD3, TERF1, ZXDB, MYB, ZNF680, PIAS1, ZNF331, SMAD1, L3MBTL2, KLF16, USF1, BCL11A, SP1, NR4A1, IKZF5, REST, POU2F3, ZHX1, ASH2L, PHIP, TCF3, FOXP1, BCOR, SMC3, ELL2, STAG1, STAG2, SKI, PPARG, FOXA2, MTA3, CBX3, CHD2, EBF1, MIER2, ZSCAN16, ZNF692, GTF2B, ZNF30, MAFF, ZNF574, MEF2C, CDK9, HOXB13, ZNF580, KDM1A, YY1, RELA, HIF1A, OTX2, GATA3, BATF, TAL1, MAX, GATA1, ZNF143, CEBPG, SP7, GFI1B, TCF7L2, KDM5B, TP53, NFKB1, ZSCAN22, MYOD1, BRD2, ELF3, KAT8, ARRB1, TBX21, NFKBIZ, AR, ARID4B, TAF1, ZNF324, EGLN2, RB1, ZBTB26, RNF2, HSF1, BRD4, ILF3, JUND, ZNF440, AHR

Target gene symbol (double-evidenced CRMs): IL10RB,SETD4,MRPS6,RCAN1,CFAP298-TCP10L,SLC5A3,ATP5PO,RUNX1,AP000295.1,CBR3,MORC3,CRYZL1,IFNAR2,AP000311.1,SON,DONSON,ITSN1,CBR1,IFNGR2,DOP1B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 4

Number of somatic mutations (non-coding): 22

Related genes and loops

Related gene: ENSG00000265590, ENSG00000249624, ENSG00000159110, ENSG00000243646, ENSG00000159128, ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205758, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000159200, ENSG00000159216, ENSG00000185917, ENSG00000159228, ENSG00000159231, ENSG00000142197, ENSG00000159256,

eachgene

Deatailed information for cohesin site CDBP00417707