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Basic information

CohesinDB ID: CDBP00417710

Locus: chr21-34366487-34368638

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE93080, GSE86191, GSE101921, ENCSR806UKK, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE130140, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, CUTLL1, Liver, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 64% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.289

Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 65% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 48%, "14_ReprPCWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, HMG20A, ZNF660, ZSCAN5C, SOX2, FOXA1, RXRB, HNRNPK, NFIC, SETX, ZNF362, ZBTB44, WDHD1, ZNF444, MXD4, SMARCE1, MITF, JMJD1C, ZNF629, TEAD1, BCLAF1, ELF1, ZNF217, ESR1, OCA2, ZNF561, CTCF, JUN, TCF12, EP300, BAF155, LMO1, GATA6, SOX5, DPF2, IRF4, RFX5, DEK, DDX20, SMC1, TEAD4, GATAD2A, TFAP2C, EED, MLX, POU2F2, CHD8, ZSCAN5D, POU5F1, CDK7, TOP2A, ZSCAN21, SRF, DDX5, SAP130, ARID3A, ERG, MYC, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, XRCC5, NKX3-1, MIER3, NR2F6, ZNF750, CEBPB, NR3C1, CREB1, CCAR2, ZNF652, EBF3, TRPS1, SPI1, MIXL1, HDAC2, GATA2, ZNF644, MXD3, FLI1, HCFC1, ZGPAT, SMARCA5, MRTFB, RUNX1, THAP11, BCL6, SMC1A, CEBPA, EZH2phosphoT487, NKX2-2, SOX13, ZFX, AFF4, SIN3A, SMAD3, ZNF770, ERG3, CBX8, ZNF654, TRIM22, SMARCC1, PRDM10, ZBTB2, ZNF384, ZNF35, RUNX2, GATA4, ZNF184, GR, PBX4, ARNT, SMAD4, NFYA, ZNF518A, FOS, HMGXB4, MED1, TEAD3, TERF1, SCRT2, PIAS1, SMAD1, ZNF22, KLF16, USF1, BCL11A, TFAP2A, SP1, HNF4A, REST, ZHX1, ASH2L, FOXP1, SMC3, ELL2, STAG1, STAG2, PPARG, FOXA2, CBX3, ZNF692, GTF2B, MAFF, ZNF574, TCF7, ZNF580, HOXB13, KDM1A, YY1, RELA, TARDBP, ZIC2, HIF1A, OTX2, GATA3, MAX, GATA1, ZNF143, CEBPG, SP7, TCF7L2, KDM5B, TP53, NFKB1, ELF3, KAT8, ARID4B, AR, YAP1, EGLN2, HSF1, RNF2, BRD4, ILF3, JUND, SCRT1, TBX2, ZNF24, AHR

Target gene symbol (double-evidenced CRMs): RUNX1,CFAP298-TCP10L,SLC5A3,ATP5PO,MRPS6,AP000295.1,IFNAR2,CBR1,DONSON,ITSN1,CRYZL1,AP000311.1,IL10RB,SETD4,IFNGR2,SON,RCAN1,CBR3,DOP1B,MORC3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 6

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene: ENSG00000265590, ENSG00000249624, ENSG00000159110, ENSG00000243646, ENSG00000159128, ENSG00000159140, ENSG00000159147, ENSG00000249209, ENSG00000205758, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000159200, ENSG00000159216, ENSG00000185917, ENSG00000159228, ENSG00000159231, ENSG00000142197, ENSG00000159256,

eachgene

Deatailed information for cohesin site CDBP00417710