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Basic information

CohesinDB ID: CDBP00417744

Locus: chr21-34516659-34519824

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE165895, GSE138405, GSE67783, GSE86191, GSE76893, GSE101921, GSE135093, GSE152721, GSE120943, GSE206145-NatGen2015, GSE112028, GSE138105, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE93080, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, GSE85526, ENCSR000ECE, ENCSR000BMY, ENCSR767DFK, ENCSR495WGO, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE55407, ENCSR167MTG, ENCSR956LGB, GSE110061, GSE129526, GSE111913, GSE155324, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE131577

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, Ishikawa, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, THP-1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, Hep-G2, MCF-10A, A-549, HUVEC, HCAEC, GM19238, Neutrophil, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 41% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.378

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 39%, "4_Tx": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, KDM3A, HDGF, PAX5, TEAD1, LMO2, SOX5, PAX8, KMT2B, GATAD2A, NANOG, ZNF263, POU5F1, TOP2A, HHEX, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, HCFC1, MXI1, HCFC1R1, RUNX1, CEBPA, TET2, ZNF654, TBX3, SP5, TRIM22, SMARCC1, ZBTB2, SOX11, ATF2, SMARCB1, SMAD1, EVI1, IKZF5, ARID2, ETV4, CBFA2T2, CBX3, CREM, SS18, PAF1, WT1, MEF2C, NEUROD1, JUNB, ZFP36, BATF, MAF1, KLF4, ZFP69B, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, SCRT1, ILF3, XBP1, HNF1A, PBX2, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, RUNX3, CBFB, TP63, MITF, ZNF467, JMJD1C, ELF1, RBM39, SNAI2, CTCF, JUN, L3MBTL4, MNT, IRF4, RBPJ, TFAP2C, MLX, YBX1, ZSCAN21, ZBTB17, ZBTB48, ZNF317, SRF, DDX5, NBN, ONECUT1, ZNF2, HOMEZ, FOXP2, RXRA, NKX3-1, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, CCAR2, TBL1XR1, KLF8, GRHL2, SSRP1, SMARCA5, NFIL3, CC2D1A, THAP11, SOX13, ZNF770, ZNF18, ARNT, ZNF48, PRDM9, PBX3, HMGXB4, TEAD3, U2AF1, KLF9, USF1, SP1, BCL11A, TFAP2A, ATF7, ASH2L, CTBP2, SMC3, STAG1, STAG2, TRP47, AGO1, MTA3, EBF1, ESR2, ZNF580, ZKSCAN1, KDM1A, ZIC2, GATA3, NRIP1, ZNF143, AGO2, TP53, NFKB1, BRD2, PHF5A, KAT8, EGR1, RB1, RNF2, BRD4, JUND, CUX1, PGR, SOX2, PATZ1, UBTF, TFAP4, SIN3B, CHD7, ZNF444, MXD4, KLF6, ESR1, KLF1, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, ZNF652, SPI1, HDAC2, INTS13, NCOA2, ETV5, BCL6, SIN3A, ERG3, MYBL2, CREBBP, ZNF384, ZNF35, RARA, NFYC, SMAD4, CDK8, ZEB1, ZMYM3, SUPT16H, RBM22, MAFK, HNF4A, REST, HNRNPLL, FOXP1, AATF, PPARG, TBL1X, ZNF692, TCF7, FOXO3, RELA, TARDBP, SKIL, MAX, GFI1B, NR2F1, KDM5B, PKNOX1, MYOD1, AR, DMAP1, AHR, FOSL2, HMG20A, LCORL, SUZ12, RBFOX2, ZNF28, ZFHX2, ZNF90, CTCFL, MECOM, CDX2, KLF5, BCLAF1, TRIM28, RCOR2, MLL, USF2, TCF12, EP300, GATA6, PRDM4, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, GATAD1, ARID3A, ASCL1, MIER1, RAD21, GRHL3, XRCC5, ZNF614, NFE2, JMJD6, TRPS1, TFE3, HBP1, IRF1, ZNF681, ZGPAT, MRTFB, ATF1, PTBP1, SMC1A, SIRT6, FIP1L1, ZFX, SMAD3, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, GR, PBX4, FOS, MED1, CEBPD, MYB, SCRT2, ZNF3, NIPBL, ZBTB7A, POU2F3, TCF3, SKI, FOXA2, MIER2, ZBTB33, CDK9, HOXB13, YY1, BRCA1, SP140, HIF1A, OTX2, GATA1, TLE3, CEBPG, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB42, NOTCH3, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): RUNX1,ITSN1,AP000311.1,SLC5A3,SMIM11A,ATP5PO,RCAN1,MRPS6,SETD4

Function elements

Human SNPs: .

Number of somatic mutations (coding): 522

Number of somatic mutations (non-coding): 58

Related genes and loops

Related gene: ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000205670, ENSG00000159200, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00417744