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Basic information

CohesinDB ID: CDBP00417746

Locus: chr21-34523800-34530931

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR760NPX, GSE126634, ENCSR000BLY, GSE25021, ENCSR150EFU, GSE105028, GSE103477, GSE111537, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, ENCSR000DZP, GSE143937, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, GSE135093, GSE206145-NatGen2015, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE116344, GSE138105, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, GSE206145, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR000BMY, ENCSR620NWG, ENCSR635OSG, ENCSR748MVX, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS

Cell type: RH4, SLK, OCI-AML-3, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, K-562, HFFc6, DKO, H1-hESC, SNYDER, Monocytes, MB157, GM12878, SK-N-SH, RT-112, HeLa-Tet-On, HAP1, Macrophage, THP-1, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HCAEC, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 37% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.600

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 23%, "7_Enh": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, HLF, RXRB, MLL4, KDM3A, ZBTB44, ZNF322, IKZF3, ZNF320, TEAD1, ZNF121, ZNF561, SOX5, DEK, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, BRD3, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, ZBTB21, SMARCA4, UBN1, RCOR1, NR2F6, CD74, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, RELB, RUNX1, CEBPA, NKX2-2, HDAC1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ATF2, FOXM1, SMARCB1, PIAS1, NR1H2, C11orf30, MBD1, ARID2, IKZF5, ELL2, ETV4, NFATC3, MEF2B, CBX3, CREM, CHD2, PAF1, SS18, NFATC1, ZSCAN16, WT1, JUNB, TCF4, BATF, KLF4, ZFP69B, ZBTB6, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, FOSL1, SMARCA2, ZNF660, HNF1A, XBP1, ZNF101, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, RUNX3, TP63, ZSCAN4, MYOG, MAF, JMJD1C, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, MNT, ZBTB20, DPF2, IRF4, ZNF350, ZNF280A, PDX1, RBPJ, TFAP2C, MLX, ZSCAN21, ZBTB17, ZBTB48, ZNF317, NONO, SRF, CHD4, ZNF329, ONECUT1, KDM4A, HOMEZ, ZNF2, TSHZ1, LHX2, RXRA, NKX3-1, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, SSRP1, NFIL3, THAP11, ZBTB24, EZH2phosphoT487, LDB1, AFF4, SOX13, POU4F2, ZNF770, SP3, ARNT, BACH1, DAXX, ZNF48, ZEB2, PBX3, MAFB, ZNF10, HMGXB4, TEAD3, ZXDB, ZNF680, KLF9, ZBTB18, TBX5, SP1, BCL11A, ATF7, ASH2L, PRDM6, SMC3, STAG1, ZNF394, TRP47, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, KDM1A, ZNF222, ZIC2, PCGF1, GATA3, TAL1, ZNF143, AGO2, TP53, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, TBX21, EGR1, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, PGR, SOX2, PATZ1, RING1B, UBTF, TFAP4, SIN3B, CHD7, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ESR1, TP73, ZNF695, SOX4, E2F6, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, ZSCAN5A, ERG2, HIC1, TBP, HNF4G, HOXC5, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, EZH2, ZNF652, MRTFA, SPI1, HDAC2, ZNF490, NCOA2, ZNF554, ZNF76, ETV5, BCL6, SIN3A, ERG3, MEF2A, MYBL2, RARA, ZNF384, CREBBP, ZNF35, NFYC, HMGB2, SMAD4, ZNF518A, CDK8, ZEB1, SPDEF, SUPT16H, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, ZNF816, PPARG, ZNF692, GTF2B, ZNF30, ZNF574, FOXO3, ZNF318, RELA, MAX, ZNF613, ZNF223, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, MYOD1, AR, YAP1, ZNF324, HEXIM1, ZNF280D, DMAP1, AHR, FOSL2, ZNF391, HMG20A, ZSCAN5C, E2F7, SUZ12, RBFOX2, ZFHX2, INSM2, NFIC, ZNF362, PRDM1, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, ZNF425, CHD8, BRD1, MYCN, CDK7, ZNF205, GATAD1, ARID3A, ZNF341, RAD21, GRHL3, PROX1, XRCC5, ZNF614, ZNF639, ARNTL, ZNF750, ZNF85, FEZF1, TFE3, EHF, HBP1, IRF1, ZGPAT, ZNF418, ZNF766, MRTFB, MYF5, ATF1, PTBP1, SMC1A, MAFG, ZNF335, ZFX, SMAD3, CBX8, TWIST1, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, OSR2, GR, ZNF184, ZSCAN30, PBX4, CHD1, FOS, MED1, ZNF558, MYB, CEBPD, SETDB1, KLF16, NIPBL, ZBTB7A, PHIP, TCF3, SKI, NELFA, FOXA2, RBBP5, ZNF600, MIER2, FOXF1, ZBTB33, CDK9, HOXB13, YY1, BRCA1, SP140, HIF1A, ZNF449, GATA1, CEBPG, SP7, NR2F2, ZNF165, ZNF843, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB42, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): SMIM11A,RCAN1,RUNX1,SLC5A3,SETD4,ATP5PO,ITSN1,AP000311.1,MRPS6

Function elements

Human SNPs: .

Number of somatic mutations (coding): 351

Number of somatic mutations (non-coding): 53

Related genes and loops

Related gene: ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000205670, ENSG00000159200, ENSG00000159216, ENSG00000185917,

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Deatailed information for cohesin site CDBP00417746