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Basic information

CohesinDB ID: CDBP00417748

Locus: chr21-34532557-34533261

Data sourse: GSE206145-GSE177045, GSE67783, GSE98367, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE103477

Cell type: MCF-7, MDM, RPE, Fibroblast, THP-1, K-562, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: Mau2,SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 53%, "5_TxWk": 41%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, SMC1A, MEIS1, SS18, ZFX, FOXA1, RELA, RUNX2, MYC, RAD21, GRHL3, ARNT, TAL1, ZNF143, PRDM14, MED1, NR3C1, RCOR2, ESR1, TBX5, TRPS1, BRD2, CTCF, SP1, SPI1, BHLHE40, PAX3-FOXO1, IRF1, BRD4, MAZ, STAG1

Target gene symbol (double-evidenced CRMs): RUNX1,SMIM11A,ITSN1,AP000311.1,RCAN1,ATP5PO

Function elements

Human SNPs: .

Number of somatic mutations (coding): 16

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000205670, ENSG00000159200, ENSG00000159216,

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Deatailed information for cohesin site CDBP00417748