- Basic information
- CohesinDB ID: CDBP00417772
- Locus: chr21-34581350-34584275
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, A-549, HUVEC, HCAEC, GM19238, HeLa, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 71% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.233
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
93% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 39%,
"7_Enh": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, FOSL1, PGR, ZNF675, SOX2, XBP1, KDM4B, FOXA1, PBX2, ZNF90, ATF3, BMI1, NFIC, ZFP64, RUNX3, ZNF444, ATF4, CBFB, MXD4, SMARCE1, TP63, MITF, ZNF736, JMJD1C, TEAD1, BCLAF1, TRIM28, RBM39, SNAI2, ZNF217, ESR1, OCA2, TP73, JUN, CTCF, TCF12, KLF1, MNT, LMO1, SOX5, DPF2, PAX8, IRF4, SOX6, ZNF410, E2F1, ZNF528, SMC1, TEAD4, FOXA3, GATAD2A, TFAP2C, EED, POU2F2, CHD8, BRD1, ZSCAN5D, MYCN, POU5F1, TOP2A, CTBP1, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, DUX4, SRF, GATAD1, NBN, ARID3A, TBP, HOXC5, ERG, PBX1, OGG1, MYC, SMARCA4, ARID1B, RAD21, GRHL3, NKX2-1, BATF3, GABPA, STAT3, APC, ZNF614, XRCC5, NKX3-1, IKZF1, RCOR1, NFE2, NR2F6, NR3C1, CEBPB, SRSF3, ZNF750, ESRRA, STAT5B, KMT2A, CREB1, GRHL2, ZNF652, ZHX2, SPI1, HES1, MIXL1, GATA2, MXD3, DRAP1, MXI1, ETV5, RUNX1, THAP11, SMC1A, CBX1, CEBPA, HDAC1, SOX13, ZFX, SMAD3, CBX8, SP5, TRIM22, SMARCC1, MEF2A, CREBBP, ZNF384, ZBTB2, NOTCH1, RUNX2, CDK6, GATA4, ZNF184, PBX4, DAXX, ARNT, NRF1, ATF2, PRDM9, HMBOX1, SMAD4, ZEB2, PBX3, MAFB, CBFA2T3, FOS, HMGXB4, CDK8, FOXM1, ETV6, MED1, ZEB1, TEAD3, CEBPD, MYB, SCRT2, PML, SMAD1, ZNF3, KLF9, L3MBTL2, TBX5, EVI1, SETDB1, STAT5A, RBM22, MAFK, BCL11A, SP1, GSPT2, IKZF5, REST, ZBTB7A, ATF7, ASH2L, AFF1, TCF3, SMC3, STAG1, STAG2, MLLT1, CBFA2T2, MEF2B, PPARG, TBL1X, MTA3, EBF1, CREM, NFATC1, MIER2, ZNF692, GTF2B, WT1, ZBED1, MEF2C, TCF7, CDK9, ZNF580, BCL3, ZNF318, KDM1A, YY1, RELA, JUNB, SP140, ZFP36, HIF1A, SKIL, GATA3, BATF, MGA, TAL1, MAX, NRIP1, GATA1, ZNF143, HAND2, PLAG1, CEBPG, KLF4, BCL11B, NCOA3, GFI1B, NR2F2, NR2F1, KDM5B, TP53, MYOD1, BRD2, ELF3, BHLHE40, AR, ARID4B, ZBTB40, EGLN2, HSF1, NCOR1, NOTCH3, BRD4, JUND, SCRT1, RNF2, IKZF2, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): SMIM11A,RCAN1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 39
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000205670,
ENSG00000159200,
- Related loop:
chr21:34350000-34375000~~chr21:34575000-34600000,
chr21:34508611-34511592~~chr21:34582165-34583641,
chr21:34508615-34511741~~chr21:34581754-34584168,
chr21:34508630-34511686~~chr21:34581785-34584141,
chr21:34508649-34511612~~chr21:34581736-34583658,
chr21:34508650-34511829~~chr21:34581759-34584645,
chr21:34508652-34511719~~chr21:34581526-34583641,
chr21:34508655-34511778~~chr21:34581832-34584557,
chr21:34508676-34511542~~chr21:34582256-34583632,
chr21:34508680-34511707~~chr21:34581775-34584106,
chr21:34508686-34511802~~chr21:34581746-34584166,
chr21:34508705-34511720~~chr21:34581803-34583823,
chr21:34508719-34511659~~chr21:34581890-34583607,
chr21:34508750-34512867~~chr21:34582003-34583678,
chr21:34508753-34511486~~chr21:34582204-34583628,
chr21:34508793-34511654~~chr21:34581884-34584059,
chr21:34509466-34511758~~chr21:34582034-34583637,
chr21:34509521-34511696~~chr21:34581875-34583641,
chr21:34509540-34511703~~chr21:34581325-34584001,
chr21:34509573-34511708~~chr21:34581787-34584086,
chr21:34509741-34511700~~chr21:34582016-34584092,
chr21:34509752-34511516~~chr21:34582035-34584113,
chr21:34509872-34511601~~chr21:34582033-34583700,
chr21:34509887-34511738~~chr21:34581871-34583664,
chr21:34509944-34511541~~chr21:34582165-34583659,
chr21:34509993-34511503~~chr21:34582193-34583617,
chr21:34516834-34518581~~chr21:34581775-34584106,
chr21:34516916-34518686~~chr21:34581803-34583823,
chr21:34517019-34518429~~chr21:34582165-34583659,
chr21:34517056-34518483~~chr21:34581736-34583658,
chr21:34524254-34527736~~chr21:34581746-34584166,
chr21:34543283-34546348~~chr21:34575254-34577002,
chr21:7800000-7825000~~chr21:34575000-34600000,