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Basic information

CohesinDB ID: CDBP00417778

Locus: chr21-34595132-34597504

Data sourse: GSE118494, ENCSR167MTG, GSE67783, GSE72082, GSE86191, GSE138405, ENCSR000BLS, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, ENCSR000ECS

Cell type: RPE, Hela-Kyoto, Fibroblast, HCT-116, Hep-G2, HeLa-S3, IMR-90, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.900

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 34%, "5_TxWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: XBP1, FOXA1, PBX2, UBTF, ZFHX2, THAP1, CDX2, KLF5, TRIM28, ETV1, NFE2L2, CTCF, JUN, EP300, KLF1, BAF155, DPF2, TEAD4, GATAD2A, PDX1, ZSCAN5D, POU5F1, MYCN, ID3, CTBP1, ZNF317, ZBTB48, DUX4, STAT1, SAP130, ERG2, ASCL1, MYC, RAD21, FOXP2, GRHL3, RXRA, XRCC5, ZNF614, RCOR1, NFE2, HNRNPH1, NR3C1, CEBPB, HNRNPL, ZBTB11, TBL1XR1, PHF8, GATA2, ATF1, RUNX1, CTNNB1, BCL6, ZNF585A, HDAC1, LDB1, NKX2-2, CBX1, SOX13, ZFX, TET2, ERG3, SMARCC1, MEF2A, RARA, ZNF384, RUNX2, GATA4, ARNT, PRDM9, CBFA2T3, MED1, ZMYM3, SMAD1, KLF9, TBX5, RBM22, BCL11A, SP1, HNF4A, NKX2-5, ZBTB7A, RBM25, ATF7, HNRNPLL, BCOR, SMC3, STAG1, TRP47, KLF13, PPARG, CBX3, MTA3, CREM, FOXA2, SS18, WT1, FOXF1, ZNF823, KDM1A, YY1, RELA, NEUROD1, SP140, ZFP36, OTX2, TAL1, MAX, GATA1, GFI1B, NR2F2, PKNOX1, ZNF334, EGR2, BRD2, BHLHE40, AR, RXR, EGR1, ZBTB26, RNF2, MYNN, BRD4, ILF3, JUND, CLOCK, MAZ, MEF2D

Target gene symbol (double-evidenced CRMs): RCAN1,SMIM11A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 24

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200,

eachgene

Deatailed information for cohesin site CDBP00417778