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Basic information

CohesinDB ID: CDBP00417779

Locus: chr21-34598744-34600193

Data sourse: GSE131606, GSE104888, ENCSR000BSB, GSE138405, GSE129526, GSE206145-NatGen2015, ENCSR153HNT, GSE121355, GSE68388, GSE126990, ENCSR000ECS

Cell type: Hela-Kyoto, Fibroblast, HCT-116, HeLa-S3, K-562, HuCC-T1, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 44%, "5_TxWk": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: TRIM25, PGR, FOSL1, ZNF660, NME2, XBP1, FOXA1, HLF, RXRB, HNRNPK, ATF3, NFIC, INSM2, ZNF362, ZBTB44, PRDM1, CHD7, ZNF189, PAX5, CDX2, ZNF467, ZNF629, TEAD1, KLF6, SNAI2, ESR1, CTCF, TCF12, JUN, EP300, BAF155, KLF1, SOX5, SOX4, ZNF528, TEAD4, GATAD2A, PDX1, RBPJ, GLIS1, NANOG, CHD8, ZSCAN5D, MYCN, POU5F1, RUNX1T1, KDM4C, ZNF263, ZSCAN21, ZBTB17, ZBTB48, ZSCAN5A, STAT1, ZNF317, SRF, SAP130, HNF4G, ERG, HOXC5, ZNF341, ONECUT1, MYC, SMARCA4, RAD21, LHX2, GRHL3, RXRA, PROX1, STAT3, XRCC5, ZNF614, APC, NKX3-1, RCOR1, NR2F6, ZNF639, ARNTL, NR3C1, CEBPB, ZNF750, CREB1, ZHX2, SPI1, MIXL1, EHF, HDAC2, GATA2, FLI1, NFIL3, ZNF554, RUNX1, BCL6, CEBPA, NKX2-2, SOX13, ZFX, SIN3A, SMAD3, PCBP2, TET2, ERG3, CBX8, ZNF770, SMARCC1, PRDM10, RARA, CREBBP, ZNF35, ZNF133, GATA4, OSR2, ZNF184, DAXX, PBX4, ARNT, ZNF48, SMAD4, ZEB2, PBX3, FOS, CDK8, SNRNP70, TEAD3, ZEB1, CEBPD, SCRT2, C11orf30, RBM22, MAFK, SP1, NIPBL, BCL11A, HNF4A, ASH2L, HNRNPLL, HOXA9, PHIP, FOXP1, SMC3, ILK, STAG1, NFATC3, ZNF394, TRP47, CBFA2T2, PPARG, TBL1X, FOXA2, CBX3, CHD2, PAF1, ZNF316, WT1, MAFF, FOXF1, HOXB13, KDM1A, YY1, RELA, ZNF19, JUNB, SP140, ZFP36, TCF4, OTX2, GATA3, MAX, CEBPG, KLF4, SP7, TCF7L2, TP53, ZNF334, ELF3, BRD2, AR, PAX3-FOXO1, ZNF324, ZNF366, ZBTB26, RNF2, HSF1, BRD4, SCRT1, NOTCH3, JUND, MAZ, ZSCAN23, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): ATP5PO,RUNX1,AP000311.1,RCAN1,IFNAR2,AP000295.1,MRPS6,SMIM11A,SLC5A3,ITSN1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 21

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000249624, ENSG00000159110, ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000205670, ENSG00000159200, ENSG00000159216,

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Deatailed information for cohesin site CDBP00417779