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Basic information

CohesinDB ID: CDBP00417784

Locus: chr21-34612457-34613145

Data sourse: GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 25%, "15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF675, FOXA1, RXRB, MLL4, KDM3A, MEN1, THAP1, ZBTB44, ZNF322, IKZF3, MORC2, PAX5, ZNF320, TEAD1, LMO2, OCA2, PITX3, HDAC8, ZNF561, ZNF577, ZNF507, E4F1, ARID5B, SOX5, PAX8, E2F4, ZNF410, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, BRD3, CTBP1, STAT1, SAP130, ERG, ZBTB8A, EZH1, SMARCA4, RFX1, FOXK2, ZNF398, RCOR1, NR2F6, NFRKB, DACH1, CEBPB, HNRNPL, CREB1, DDX21, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, HCFC1, MXI1, NR2C2, DRAP1, RELB, RUNX1, CEBPA, HDAC1, NKX2-2, SP5, TRIM22, SMARCC1, PRDM10, ZXDC, TFDP1, ELK1, ATF2, SNIP1, FOXM1, SP2, SMARCB1, GMEB1, TERF1, PIAS1, C11orf30, EVI1, MBD1, GSPT2, IKZF5, ARID2, OVOL3, RBM25, MBD2, ELL2, ZNF704, HMGB1, ETV4, NFATC3, CBFA2T2, ZNF207, CBX3, CREM, CHD2, SS18, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, TCF4, ZFP36, BATF, MAF1, SPIB, PLAG1, ZFP69B, KLF4, BCL11B, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, FOSL1, ZNF660, XBP1, KDM4B, PBX2, HNRNPK, ATF3, ZFP64, RUNX3, CBFB, DPF1, TP63, MITF, ZNF467, INTS11, MAF, JMJD1C, ELF1, RBM39, SNAI2, KLF10, SMAD5, CTCF, JUN, TAF3, MNT, LMO1, ZBTB20, DPF2, RYBP, SIX5, IRF4, PDX1, RBPJ, TFAP2C, MLX, ZSCAN21, ZBTB17, ZBTB48, ZNF317, NONO, SRF, DDX5, PBX1, ONECUT1, KDM4A, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, FOXK1, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SMARCA5, NFIL3, THAP11, CTNNB1, ZBTB24, EZH2phosphoT487, AFF4, SOX13, POU4F2, ZNF770, ZMIZ1, ZNF18, SP3, ARNT, BACH1, ZNF48, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, HMGXB4, TEAD3, DIDO1, ZXDB, U2AF1, KLF9, TBX5, USF1, SP1, BCL11A, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MEIS1, ESR2, ZNF580, KLF7, ZKSCAN1, KDM1A, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, ZNF141, TP53, ZNF334, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, JUND, BRD4, SPIN1, CUX1, ZSCAN23, TBX2, FANCL, SOX2, PATZ1, RING1B, UBTF, TFAP4, SIN3B, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, KLF1, SOX9, SOX4, E2F6, TRIM24, RFX5, U2AF2, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ELK4, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, ZNF343, INO80, DNMT3B, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ZNF76, ZNF554, NFYB, ETV5, BCL6, SIN3A, ERG3, MYBL2, RARA, ZNF35, NFYC, CREBBP, TAF15, ZNF354B, ZNF384, SMAD4, ZNF518A, CDK8, ZEB1, NCOA1, SREBF2, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF574, YY2, RELA, TARDBP, SKIL, MGA, MAX, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, MYOD1, T, AR, KMT2D, ZNF324, HEXIM1, ZNF395, AHR, DMAP1, FOSL2, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, INSM2, NFIC, CTCFL, KLF14, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, ZFP91, TCF12, EP300, BAF155, GATA6, PRDM4, SOX6, CREB3, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, GMEB2, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, FEZF1, HBP1, TFE3, EHF, IRF1, ZNF681, SREBF1, ZGPAT, NAB2, MRTFB, ATF1, PTBP1, CBX1, SMC1A, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, PCBP2, CBX8, TWIST1, IRF2, NCOA6, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, ZSCAN30, NRF1, PBX4, NR2C1, FOS, CHD1, TGIF2, MED1, KDM6B, MYB, SCRT2, ZNF558, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, ZNF783, SKI, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, CDK9, HOXB13, YY1, BRCA1, SP140, HIF1A, OTX2, ZNF519, ZNF740, ZNF449, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF213, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): SLC5A3,AP000311.1,SMIM11A,AP000295.1,ITSN1,RCAN1,IFNAR2,RUNX1,MRPS6,ATP5PO

Function elements

Human SNPs: .

Number of somatic mutations (coding): 9

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000249624, ENSG00000159110, ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000198743, ENSG00000205670, ENSG00000159200, ENSG00000159216,

eachgene

Deatailed information for cohesin site CDBP00417784