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Basic information

CohesinDB ID: CDBP00417794

Locus: chr21-34642001-34643001

Data sourse: GSE38395, GSE93080, ENCSR000DZP, GSE206145, ENCSR000BMY, ENCSR153HNT, GSE68388, GSE50893, GSE165895

Cell type: GM2630, GM2610, GM12878, GM2588, GM12890, hLCL, K-562, HFFc6, HuCC-T1, B-cell

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.889

Subunit: NIPBL,SA1,Rad21,SMC1,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 39%, "15_Quies": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, XBP1, MLL4, HDGF, TSC22D4, NFIC, RUNX3, CBFB, PAX5, TP63, MITF, BACH2, JMJD1C, ELF1, BCLAF1, TEAD1, KLF6, SNAI2, ETV1, TRIM28, ZNF217, LMO2, OCA2, TP73, USF2, CTCF, TCF12, SND1, EP300, JUN, KLF1, DPF2, IRF4, ZNF350, TEAD4, RBPJ, EED, YBX1, POU2F2, ZSCAN5D, ZNF263, RUNX1T1, ID3, KDM4C, MTA2, ZSCAN5A, STAT1, NBN, ARID3A, ERG, HOXC5, PBX1, ETS1, MYC, RAD21, GRHL3, PROX1, GABPA, STAT3, IKZF1, NFE2, TERF2, NR3C1, KMT2A, ZHX2, SPI1, GATA2, GATAD2B, FLI1, SMARCA5, RELB, RUNX1, SMC1A, ZBTB24, ZFX, SMAD3, ERG3, TRIM22, MEF2A, RUNX2, ARNT, BACH1, ATF2, ETV6, PBX3, FOXM1, CDK8, SNRNP70, MED1, ZEB1, TERF1, MYB, SMAD1, EVI1, MAFK, SP1, BCL11A, NIPBL, ATF7, ASH2L, TCF3, SMC3, MLLT1, STAG1, NFATC3, MEF2B, MTA3, CREM, EBF1, HDAC6, MEIS1, GTF2B, WT1, TCF7, CDK9, BCL3, YY1, RELA, TARDBP, JUNB, SP140, TCF4, SKIL, BATF, TAL1, MAX, ZNF143, GATA1, KLF4, NCOA3, NR2F1, KDM5B, TP53, ZNF687, PKNOX1, MED, ELF3, TBX21, BHLHE40, PAX3-FOXO1, AR, TAF1, YAP1, RB1, RNF2, IKZF2, SCRT1, BRD4, NOTCH3, MAZ, AHR

Target gene symbol (double-evidenced CRMs): MRPS6,AP000311.1,ATP5PO,SMIM11A,ITSN1,RCAN1

Function elements

Human SNPs: Psoriasis

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 5

Related genes and loops

Related gene: ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000243927, ENSG00000205670, ENSG00000159200,

eachgene

Deatailed information for cohesin site CDBP00417794