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Basic information

CohesinDB ID: CDBP00417816

Locus: chr21-34701621-34704879

Data sourse: ENCSR000EFJ, GSE67783, GSE86191, GSE138405, ENCSR000HPG, ENCSR404BPV, GSE206145, GSE85526, GSE206145-NatGen2015, ENCSR153HNT, ENCSR000EHX, GSE126990, GSE165895

Cell type: RPE, Hela-Kyoto, Fibroblast, HCT-116, HEKn, Neurons-H1, IMR-90, SK-N-SH, K-562, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 7% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.878

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 29%, "14_ReprPCWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, SMARCA2, XBP1, PBX2, ZFHX2, ATF3, CTCFL, ELF1, TRIM28, NFE2L2, ESR1, HDAC8, USF2, CTCF, JUN, TEAD4, TFAP2C, ZSCAN5D, MYCN, ID3, ZBTB48, ZSCAN5A, ZNF485, ERG2, HNF4G, ERG, MYC, RAD21, GABPA, STAT3, RCOR1, ZNF750, NR3C1, CEBPB, EZH2, HDAC2, GATA2, MXI1, RUNX1, SMC1A, BCL6, AFF4, ZFX, PALB2, TET2, ERG3, PRDM10, RUNX2, CDK6, NRF1, ARNT, FOS, MED1, CEBPD, ZNF3, L3MBTL2, MAFK, HNF4A, NR4A1, HNRNPLL, SMC3, STAG1, NFATC3, TRP47, PPARG, WT1, YY1, RELA, JUNB, SP140, MAX, HAND2, KLF4, NR2F2, NR2F1, ZNF334, NFKB1, MYOD1, BHLHE40, AR, YAP1, EGR1, ZBTB26, HSF1, BRD4, MAZ, BRCA1, FOSL2

Target gene symbol (double-evidenced CRMs): SETD4,RUNX1,CLIC6

Function elements

Human SNPs: .

Number of somatic mutations (coding): 24

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159212, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00417816