- Basic information
- CohesinDB ID: CDBP00417818
- Locus: chr21-34707476-34708390
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Data sourse: GSE93080, ENCSR000DZP, GSE67783, GSE155324, ENCSR000BMY, GSE50893
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Cell type: GM2630, GM2610, Lymphoblast, GM12878, GM12891, GM2255, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SMC3,Rad21,SA1,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
93% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 38%,
"14_ReprPCWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, CBX5, NME2, HDGF, ZNF90, BMI1, NFIC, RUNX3, CBFB, PAX5, ZNF736, MAF, ELF1, TRIM28, BCLAF1, NFE2L2, CTCF, TCF12, ARID5B, LMO1, DPF2, IRF4, SOX6, TEAD4, RBPJ, EED, POU2F2, ZSCAN5D, MYCN, POU5F1, CDK7, RUNX1T1, ZNF317, MTA2, ZBTB48, STAT1, NBN, ARID3A, ZNF300, ERG, ZNF341, MYC, ARID1B, BATF3, GABPA, IKZF1, RCOR1, SRSF3, STAT5B, CREB1, EZH2, GRHL2, SPI1, HDAC2, GATA2, GATAD2B, RELB, RUNX1, BCL6, SMC1A, LDB1, AFF4, ZFX, ERG3, TRIM22, MEF2A, ZBTB2, NOTCH1, ARNT, ATF2, CBFA2T3, ETV6, FOXM1, CDK8, MED1, ZEB1, PML, MYB, ZNF3, STAT5A, BCL11A, SP1, NIPBL, REST, ATF7, ASH2L, BCOR, TCF3, NCOR2, MLLT1, STAG1, NFATC3, CBFA2T2, MEF2B, MTA3, CREM, EBF1, NFATC1, GTF2B, WT1, ZBED1, MEF2C, TCF7, CDK9, BCL3, YY1, RELA, TARDBP, JUNB, AHR, SP140, ZFP36, SKIL, TCF4, BHLHE22, GATA3, BATF, TAL1, MAX, SPIB, GATA1, ZNF143, BCL11B, TP53, ZNF687, PKNOX1, EGR2, TBX21, BHLHE40, TAF1, ZBTB16, ZBTB40, EGR1, RNF2, NCOR1, BRD4, IKZF2, CLOCK, ZNF316
- Target gene symbol (double-evidenced CRMs): RUNX1,CLIC6,SETD4
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 88
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000159212,
ENSG00000159216,
ENSG00000185917,
- Related loop:
chr21:34700000-34725000~~chr21:34825000-34850000,
chr21:34700000-34725000~~chr21:34850000-34875000,
chr21:34700000-34725000~~chr21:35025000-35050000,
chr21:34700000-34725000~~chr21:35375000-35400000,
chr21:34700000-34725000~~chr21:35400000-35425000,
chr21:34700000-34725000~~chr21:35500000-35525000,
chr21:34700000-34725000~~chr21:35825000-35850000,
chr21:34700000-34725000~~chr21:35925000-35950000,
chr21:34700000-34725000~~chr21:35975000-36000000,
chr21:34700000-34725000~~chr21:36025000-36050000,