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Basic information

CohesinDB ID: CDBP00417822

Locus: chr21-34716204-34717951

Data sourse: GSE98367, ENCSR879KXD, GSE206145-NatGen2015, GSE120943, ENCSR153HNT

Cell type: K-562, Fibroblast, Monocytes, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 37%, "14_ReprPCWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, XBP1, KDM4B, FOXA1, PBX2, UBTF, HDGF, NFIC, RUNX3, PAX5, ZSCAN4, ELF1, BCLAF1, ETV1, RBM39, NFE2L2, OCA2, CTCF, JUN, EP300, E4F1, PYGO2, IRF4, TRIM24, CREB3, TEAD4, EHMT2, EED, POU2F2, CHD8, ZNF263, RUNX1T1, ID3, CTBP1, ZBTB48, STAT1, DDX5, ERG2, TBP, ERG, ETS1, MYC, EZH1, ARID1B, FOXP2, GRHL3, BATF3, GABPA, STAT3, IKZF1, RCOR1, TERF2, LEF1, STAT5B, CREB1, ZBTB11, EZH2, BMPR1A, GABPB1, SPI1, IRF1, FLI1, HCFC1, NR2C2, NCOA2, ATF1, RUNX1, BCL6, SMC1A, HDAC1, ZFX, ERG3, ZBTB2, IRF2, NOTCH1, RUNX2, ARNT, NRF1, ATF2, PRDM9, ZEB2, HMBOX1, ETV6, NR2C1, DIDO1, VEZF1, NCOA1, C11orf30, L3MBTL2, BCL11A, SP1, NR4A1, ZBTB7A, POU2F3, ATF7, BCOR, FOXP1, STAT2, ILK, STAG1, MLLT1, CBX3, MTA3, EBF1, CREM, ZNF692, YY1, RELA, TARDBP, JUNB, ZNF148, NEUROD1, ZFP36, BATF, TAL1, MAX, SPIB, NRIP1, GATA1, GFI1B, NR2F2, TP53, ZSCAN22, MYOD1, AR, ZBTB40, EGR1, HSF1, MYNN, IKZF2, BRD4, JUND, ILF3, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): RUNX1,SETD4,CLIC6

Function elements

Human SNPs: .

Number of somatic mutations (coding): 134

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159212, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00417822