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Basic information

CohesinDB ID: CDBP00417824

Locus: chr21-34719317-34720422

Data sourse: GSE104888, GSE72082, ENCSR000BSB, ENCSR000BLY, GSE121355, GSE131606, GSE108869, GSE25021, ENCSR000BUC, GSE67783, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE138105, GSE116344, ENCSR703TNG, ENCSR000BLS, GSE206145, ENCSR247LSH, ENCSR767DFK, ENCSR495WGO, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, GSE129526, ENCSR335RKQ, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS

Cell type: RH4, GM2610, SLK, HuCC-T1, RPE, GM2630, Fibroblast, HeLa-S3, GM2255, K-562, GM18486, DKO, GM12891, SK-N-SH, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, A-549, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 13% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.778

Subunit: SA1,Rad21,SMC3,SMC1,SA2,SMC3ac

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 52%, "14_ReprPCWk": 39%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, SMC1A, POU2F2, MTA3, ZFX, NME2, WT1, FOXA1, ERG3, DDX5, ZFHX2, SMARCA4, RAD21, SP140, HIF1A, NKX2-1, MED1, NR3C1, ELF1, ESR1, OCA2, CTCF, AR, NCOR1, CUX1, SMC1, SMC3, STAG1

Target gene symbol (double-evidenced CRMs): CLIC6,SETD4,RUNX1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000159212, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00417824