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Basic information

CohesinDB ID: CDBP00417828

Locus: chr21-34726071-34727333

Data sourse: GSE72082, ENCSR879KXD, GSE206145-NatGen2015, ENCSR153HNT, GSE68388, GSE116344, GSE165895

Cell type: MCF-7, Fibroblast, RH4, K-562, HuCC-T1, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 40%, "14_ReprPCWk": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, FOXO1, FOSL1, PGR, MAFG, ZSCAN5D, HDAC1, CREM, CEBPA, ID3, ZFX, SIN3A, SMAD3, STAT1, FOXA1, MEF2C, PBX2, KDM1A, RELA, ATF3, RUNX2, BRD9, SMARCA4, RFX1, ARID1B, AHR, ZFP36, BACH1, HIF1A, GRHL3, GATA3, PRDM9, ATF2, TAL1, PBX3, SPIB, FOS, GATA1, NFE2, RCOR1, CDK8, ARNTL, VDR, NR3C1, ZNF592, CEBPB, TEAD1, TRIM28, ZMYM3, NFE2L2, EZH2, ESR1, ZNF687, ZBTB6, C11orf30, MYOD1, JUN, TCF12, BCL11A, SPI1, NR4A1, AR, GATA2, TRIM24, ATF7, HSF1, JUND, BRD4, ZNF350, ATF1, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): SMIM11A,RUNX1,SETD4

Function elements

Human SNPs: Breast_cancer

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00417828