- Basic information
- CohesinDB ID: CDBP00417832
- Locus: chr21-34733994-34735235
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Data sourse: ENCSR000BTQ, GSE206145-GSE177045, GSE72082, ENCSR676MJK, GSE76893, GSE101921, GSE206145-NatGen2015, GSE68388, ENCSR703TNG, GSE25021, GSE115602
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Cell type: MCF-7, HMEC, Fibroblast, A-549, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
93% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 50%,
"14_ReprPCWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, MEIS2, FOXA1, PBX2, BMI1, WDHD1, SMARCE1, TP63, ELF1, TEAD1, KLF10, ZNF217, ESR1, CTCF, TCF12, JUN, EP300, BAF155, MNT, DPF2, PAX8, MED12, RAD51, E2F1, TEAD4, TFAP2C, CHD8, SRC, CTBP1, SRF, ERG, MYC, RAD21, NKX2-1, GABPA, STAT3, RCOR1, NR3C1, CEBPB, ESRRA, ZNF750, CREB1, GRHL2, TRPS1, ZHX2, EHF, ZSCAN2, HDAC2, GATA2, NCOA2, RUNX1, ZNF45A, CBX1, BCL6, SIN3A, ZFX, SMAD3, NFXL1, ZXDC, CREBBP, RUNX2, GR, NFIB, ARNT, PBX4, PRDM9, FOXM1, FOS, CDK8, MED1, PML, NCOA1, C11orf30, SREBF2, MAFK, NIPBL, TFAP2A, REST, ATF7, CTBP2, MBD2, STAG2, STAG1, FOXA2, ESR2, MEF2C, RELA, TARDBP, NEUROD1, AHR, JUNB, HIF1A, GATA3, TAL1, MAX, NRIP1, GATA1, ZNF143, TLE3, KLF4, ZNF592, NCOA3, NR2F2, TCF7L2, NR2F1, KDM5B, ZNF687, PKNOX1, TP53, NFKB1, MYOD1, AR, EGLN2, HSF1, BRD4, JUND, CLOCK, CUX1, ZNF24, ZNF316, FOSL2
- Target gene symbol (double-evidenced CRMs): SMIM11A,RUNX1,SETD4
- Function elements
- Human SNPs: Adolescent_idiopathic_scoliosis
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000205670,
ENSG00000159216,
ENSG00000185917,
- Related loop:
chr21:34350000-34375000~~chr21:34725000-34750000,
chr21:34725000-34750000~~chr21:34825000-34850000,
chr21:34725000-34750000~~chr21:34850000-34875000,
chr21:34725000-34750000~~chr21:34875000-34900000,
chr21:34725000-34750000~~chr21:35025000-35050000,
chr21:34725000-34750000~~chr21:35200000-35225000,
chr21:34725000-34750000~~chr21:35400000-35425000,
chr21:34725000-34750000~~chr21:35500000-35525000,
chr21:34725000-34750000~~chr21:35600000-35625000,
chr21:34725000-34750000~~chr21:35825000-35850000,
chr21:34725000-34750000~~chr21:35925000-35950000,
chr21:34725000-34750000~~chr21:36025000-36050000,