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Basic information

CohesinDB ID: CDBP00417833

Locus: chr21-34735958-34737524

Data sourse: GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE138405, GSE206145-NatGen2015, ENCSR153HNT, ENCSR703TNG, ENCSR748MVX, GSE165895

Cell type: MCF-7, Fibroblast, Hela-Kyoto, A-549, K-562, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 41%, "14_ReprPCWk": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, ZNF675, HMG20A, MEIS2, HNF1A, FOXA1, PBX2, RXRB, ZNF90, HDAC3, TEAD1, ELF1, TRIM28, ETV1, ESR1, CTCF, JUN, BAF155, EP300, DPF2, GATAD2A, PDX1, TFAP2C, NANOG, CHD8, ZSCAN5D, MYCN, DUX4, SAP130, ERG, HOXC5, MYC, RAD21, GRHL3, RXRA, GABPA, STAT3, NKX3-1, NR2F6, ARNTL, VDR, NR3C1, CEBPB, ESRRA, CREB1, BPTF, GRHL2, TRPS1, SPI1, EHF, KDM5A, HDAC2, GATA2, ZNF644, NFIL3, RUNX1, BCL6, MAFG, CEBPA, SIN3A, ZFX, SOX13, SMAD3, TWIST1, CREBBP, ZXDC, RARA, RUNX2, GATA4, GR, PBX4, DAXX, ARNT, PRDM9, HMBOX1, SMAD4, PBX3, FOXM1, FOS, MED1, TEAD3, PIAS1, C11orf30, MAFK, SP1, HNF4A, ARID1A, ASH2L, MBD2, FOXP1, STAG1, PPARG, FOXA2, MAFF, HOXB13, KDM1A, RELA, BRG1, MCM3, ZIC2, HIF1A, GATA3, MAX, ZNF143, CBX2, TLE3, CEBPG, NCOA3, NR2F2, TCF7L2, NR2F1, KDM5B, TP53, PKNOX1, ZNF334, ELF3, ZNF765, AR, ZBTB40, YAP1, EGLN2, HSF1, RNF2, BRD4, JUND, CLOCK, MAZ, AHR

Target gene symbol (double-evidenced CRMs): SETD4,SMIM11A,RUNX1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159216, ENSG00000185917,

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Deatailed information for cohesin site CDBP00417833