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Basic information

CohesinDB ID: CDBP00417836

Locus: chr21-34742264-34742467

Data sourse: GSE206145-NatGen2015, GSE86191

Cell type: Fibroblast, HCT-116

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 93% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 42%, "14_ReprPCWk": 41%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, PAX5, TEAD1, ZNF121, LMO2, ZNF561, E4F1, SOX5, PAX8, DEK, ZNF410, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, BRD3, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, RCOR1, DACH1, NR2F6, CEBPB, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, HCFC1, NR2C2, ZNF785, RUNX1, HDAC1, NKX2-2, CEBPA, TET2, ZNF654, SP5, TRIM22, SMARCC1, PRDM10, ZXDC, ZBTB2, ELK1, ATF2, FOXM1, SP2, TERF1, PIAS1, SMAD1, MBD1, ARID2, IKZF5, RBM25, ELL2, ETV4, CBFA2T2, CBX3, CREM, CHD2, SS18, WT1, MEF2C, JUNB, NEUROD1, TCF4, ZFP36, BATF, SPIB, KLF4, BCL11B, ZBTB6, ELF3, ARID4B, EGLN2, HSF1, ZBTB26, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, PBX2, ATF3, ZC3H8, THRB, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, JMJD1C, MAF, MYOG, ELF1, ZNF573, RBM39, SNAI2, CTCF, JUN, MNT, DPF2, IRF4, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, DDX5, ONECUT1, KDM4A, HOMEZ, RXRA, NKX3-1, MIER3, VDR, NR3C1, ESRRA, STAT5B, KMT2A, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, ZKSCAN5, SSRP1, NFIL3, CC2D1A, THAP11, SOX13, AFF4, ZMIZ1, ZNF18, ARNT, DAXX, ZNF48, PRDM9, ZEB2, NFYA, PBX3, ETV6, HMGXB4, ICE2, TEAD3, DIDO1, U2AF1, KLF9, SP1, BCL11A, ATF7, ASH2L, SMC3, STAG1, STAG2, MLLT1, ZNF394, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, ZKSCAN1, KDM1A, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, TP53, NFKB1, PHF5A, BRD2, KAT8, ARRB1, RB1, RNF2, BRD4, JUND, CUX1, PGR, SOX2, PATZ1, TFAP4, SIN3B, BMI1, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5A, ELK4, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, EZH2, ZNF652, SPI1, HDAC2, NCOA2, ETV5, BCL6, SIN3A, CREBBP, RARA, ZNF35, NFYC, TAF15, ZNF384, SMAD4, ZNF518A, CDK8, ZEB1, ZNF264, SREBF2, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, FOXO3, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, MYOD1, T, AR, ZNF324, DMAP1, AHR, FOSL2, HMG20A, LCORL, RBFOX2, ZNF90, NFIC, ZNF362, CTCFL, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, HNF1B, TCF12, EP300, BAF155, GATA6, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, MYCN, CDK7, ID3, RUNX1T1, MLLT3, GATAD1, ARID3A, EOMES, RAD21, GRHL3, XRCC5, ZNF614, NFE2, TCF25, ZNF750, JMJD6, TFE3, EHF, HBP1, IRF1, ZGPAT, MRTFB, ZC3H11A, ATF1, PTBP1, SMC1A, ZNF335, ZFX, FIP1L1, SMAD3, TWIST1, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, ZNF184, PBX4, NRF1, NR2C1, FOS, CHD1, TGIF2, MED1, KDM6B, MYB, SCRT2, ZNF3, L3MBTL2, KLF16, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, SKI, FOXA2, ZNF600, MIER2, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, ZNF449, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF687, NFKBIZ, BHLHE40, TAF1, ZBTB40, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): RUNX1,SMIM11A,SETD4

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00417836