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Basic information

CohesinDB ID: CDBP00417853

Locus: chr21-34774437-34775227

Data sourse: GSE206145-GSE177045, GSE72082, GSE98367, GSE138405, ENCSR879KXD, ENCSR000BLS, GSE120943, ENCSR000EDE, GSE68388, ENCSR703TNG, ENCSR000EDW, ENCSR000ECS

Cell type: MCF-7, Macrophage, Hela-Kyoto, Monocytes, Hep-G2, HeLa-S3, K-562, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 66%, "14_ReprPCWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, ZNF660, SOX2, MEIS2, NME2, PATZ1, FOXA1, HLF, SUZ12, RBFOX2, PBX2, RXRB, MLL4, TFAP4, ATF3, BMI1, THRB, CHD7, PRDM1, ATF4, ZNF273, MXD4, SMARCE1, ZSCAN4, HDAC3, ZNF736, JMJD1C, TEAD1, TRIM28, KLF6, ZNF26, NFE2L2, RCOR2, ESR1, HNF1B, TP73, ZNF217, JUN, TCF12, CTCF, EP300, BAF155, ZBTB20, ZNF157, GATA6, SOX5, DPF2, SOX9, TRIM24, RFX5, SOX6, ZNF674, E2F1, ZNF528, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, GTF2F1, TFAP2C, RBPJ, BRD3, POU5F1, ID3, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZNF317, DUX4, NONO, GATAD1, SAP130, NBN, ARID3A, DDX5, BAHD1, TBP, HNF4G, HOXC5, ZBTB21, ERG, SMARCC2, ETS1, MYC, SMARCA4, RFX1, ARID1B, RAD21, HOMEZ, PROX1, NKX2-1, RXRA, APC, STAT3, ZNF614, XRCC5, NKX3-1, RCOR1, LEF1, NFE2, NR2F6, MIER3, NFRKB, NR3C1, ESRRA, CEBPB, ZNF750, CREB1, CCAR2, TBL1XR1, EZH2, GRHL2, ZNF652, TRPS1, GABPB1, ZHX2, HES1, MIXL1, TFE3, IRF1, HDAC2, GATA2, ZNF644, DRAP1, NR2C2, ZGPAT, EP400, NFIL3, ATF1, ETV5, RUNX1, THAP11, ZNF585A, BCL6, ZBTB24, HDAC1, CEBPA, SOX13, AFF4, ZNF335, SIN3A, SMAD3, CBX8, SMARCC1, PRDM10, RARA, ZNF384, BRD9, RUNX2, GATA4, ZNF184, PBX4, DAXX, BACH1, ARNT, ATF2, HMBOX1, ZNF518A, ZEB2, FOXM1, CBFA2T3, NR2C1, SMAD4, CDK8, FOS, PBX3, SMARCB1, MED1, ZNF584, HMGXB4, TEAD3, PML, CEBPD, PIAS1, SMAD1, ZNF3, NR1H2, C11orf30, L3MBTL2, KLF16, RBM22, USF1, SP1, TFAP2A, BCL11A, HNF4A, IKZF5, ARID2, ARID1A, ZBTB7A, ATF7, ZHX1, ASH2L, POU2F3, ZNF548, CTBP2, PHIP, FOXP1, SMC3, ELL2, ZFP82, TRP47, CBFA2T2, PPARG, FOXA2, MTA3, CREM, CHD2, SS18, MIER2, ZNF692, GTF2B, FOXF1, MEF2C, TCF7, ZBTB33, CDK9, ZNF580, ZKSCAN1, ZNF318, KDM1A, ZNF589, RELA, HOXB13, JUNB, NEUROD1, ZNF830, ZFP36, HIF1A, GATA3, MGA, TAL1, MAX, NRIP1, GATA1, ZNF143, CBX2, TLE3, KLF4, CEBPG, SP7, GFI1B, NR2F2, ZKSCAN8, ZNF83, ZNF512, TCF7L2, NR2F1, ZNF791, TP53, PKNOX1, ZNF334, NFKB1, ZSCAN22, ELF3, BRD2, KAT8, BHLHE40, AR, PTRF, NFKBIZ, ARID4B, ZBTB40, YAP1, ZNF324, EGLN2, RNF2, NCOR1, BRD4, JUND, CUX1, ZNF440, IRF9, MEF2D, BRCA1, DMAP1, FOSL2

Target gene symbol (double-evidenced CRMs): CLIC6,RUNX1,SMIM11A,SETD4

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159212, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00417853