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Basic information

CohesinDB ID: CDBP00417866

Locus: chr21-34798224-34798713

Data sourse: GSE129526, GSE98367

Cell type: HCT-116, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: Rad21,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 39%, "5_TxWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, ZBTB44, IKZF3, SRSF7, TEAD1, ZNF121, OCA2, HDAC8, ZNF561, ZNF577, SOX5, PAX8, DEK, GATAD2A, JARID2, NANOG, POU5F1, BRD3, ZNF263, TOP2A, HHEX, DUX4, STAT1, ZNF563, SAP130, ERG, ZBTB8A, EZH1, SMARCA4, FOXK2, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, RUNX1, CEBPA, NKX2-2, CRY1, ZNF654, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ATF2, SMARCB1, PML, PIAS1, SMAD1, NR1H2, GSPT2, ARID2, IKZF5, OVOL3, ZNF605, MBD2, ETV4, CBFA2T2, CBX3, CREM, CHD2, PAF1, NFATC1, SS18, ZSCAN16, WT1, MEF2C, JUNB, TCF4, BATF, MAF1, PLAG1, KLF4, ZFP69B, MED, EGR2, ELF3, ARID4B, RXR, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, FOSL1, XBP1, HNF1A, ZNF101, PBX2, ZNF596, HNRNPK, ATF3, THRB, ZFP64, RUNX3, CBFB, ZSCAN4, TP63, MITF, ZNF467, MAF, MYOG, ELF1, KLF10, SMAD5, FUS, JUN, CTCF, IRF4, PDX1, TFAP2C, RBPJ, MLX, ZSCAN21, ZNF317, ZBTB48, ZBTB17, SRF, DDX5, NBN, CHD4, ONECUT1, TSHZ1, HOMEZ, FOXP2, RXRA, NKX3-1, MIER3, VDR, NR3C1, ESRRA, KMT2A, TBL1XR1, KLF8, GRHL2, EBF3, ZKSCAN5, SSRP1, NFIL3, THAP11, CTNNB1, EZH2phosphoT487, SOX13, AFF4, ZNF513, ZNF18, ARNT, DAXX, ZNF48, PRDM9, ZEB2, NCAPH2, ZNF10, MAFB, HMGXB4, TEAD3, ZXDB, U2AF1, USF1, BCL11A, SP1, TFAP2A, ATF7, ASH2L, GLIS2, PRDM6, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, AGO1, MTA3, MAFF, ESR2, ZNF580, KDM1A, BRG1, ZIC2, GATA3, TAL1, ZNF143, AGO2, TP53, ZNF334, NFKB1, ZSCAN22, PHOX2B, BRD2, PHF5A, KAT8, TBX21, EGR1, TFIIIC, BRD4, JUND, CUX1, PGR, SOX2, PATZ1, LEO1, TFAP4, CHD7, ATF4, MXD4, ZNF189, MZF1, KLF6, NFE2L2, ESR1, SOX4, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, ZSCAN5A, ZMYND8, ERG2, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, NKX2-1, GABPA, STAT3, IKZF1, SRSF3, EZH2, ZNF652, SPI1, ZNF202, HDAC2, ZNF554, ETV5, BCL6, SIN3A, ZBTB12, ERG3, MEF2A, RARA, ZNF384, ZNF35, CREBBP, TAF15, HMGB2, ZNF518A, SMAD4, CDK8, ZEB1, SUPT16H, NCOA1, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, ZNF34, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, ZNF823, TCF7, RELA, TARDBP, MAX, ZNF730, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, T, AR, HEXIM1, DMAP1, AHR, FOSL2, ZNF391, HMG20A, ZSCAN5C, RBFOX2, ZFHX2, ZNF362, CTCFL, PRDM1, CDX2, ZNF629, BCLAF1, TRIM28, ZNF557, RCOR2, HNF1B, USF2, TCF12, BAF155, EP300, GATA6, PRDM4, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, ZNF425, CHD8, BRD1, MYCN, SRC, ZNF649, GATAD1, ARID3A, ASCL1, ZNF341, EOMES, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, ZNF667, ZNF639, ARNTL, ZNF750, FEZF1, TRPS1, TFE3, EHF, IRF1, ZGPAT, ZNF766, ZIM3, MYF5, PTBP1, SMC1A, CBX1, SIRT6, FIP1L1, ZFX, SMAD3, PCBP2, RUNX2, CDK6, GATA4, OSR2, ZNF184, ZSCAN30, GR, NRF1, PBX4, SUPT5H, FOS, CHD1, MED1, KDM6B, MYB, SCRT2, CEBPD, ZNF3, SETDB1, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, SKI, FOXA2, E2F8, MIER2, ZNF600, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ZNF610, SP140, HIF1A, OTX2, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF843, NFKBIZ, BHLHE40, TAF1, ZBTB42, MYNN, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): CLIC6,RUNX1,SMIM11A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 12

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159212, ENSG00000159216,

eachgene

Deatailed information for cohesin site CDBP00417866