Deatailed information for cohesin site CDBP00417874

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  • Basic information
  • CohesinDB ID: CDBP00417874
  • Locus: chr21-34817535-34820582
  • Data sourse: ENCSR230ZWH, GSE72082, GSE116868, GSE25021, ENCSR000EDW, GSE165895, GSE67783, GSE86191, GSE76893, GSE206145-NatGen2015, GSE120943, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR167MTG, GSE111913, ENCSR054FKH, GSE68388, GSE83726
  • Cell type: MCF-7, Macrophage, RPE, Fibroblast, HCT-116, Monocytes, Hep-G2, MB157, RH4, RT-112, Liver, HSPC, HuCC-T1, HFFc6
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 8% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.844
  • Subunit: SA1,Rad21,SMC1,SA2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 91% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 23%, "4_Tx": 22%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF675, FOXA1, RXRB, MLL4, KDM3A, ZBTB44, IKZF3, PAX5, TEAD1, LMO2, MED26, PITX3, ZNF561, ZNF577, ARID5B, SOX5, DEK, RFX3, KLF3, GATAD2A, BRD3, POU5F1, ZNF263, TOP2A, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, ZBTB21, ZNF597, NFKB2, SMARCA4, RFX1, UBN1, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, RELB, RUNX1, CEBPA, TET2, TBX3, SP5, SMARCC1, PRDM10, ATF2, FOXM1, SMARCB1, TERF1, ZNF331, PIAS1, NR1H2, C11orf30, EVI1, ARID2, IKZF5, OVOL3, RBM25, ELL2, ETV4, NFATC3, MEF2B, CBX3, ZNF207, CREM, CHD2, SS18, PAF1, NFATC1, WT1, MEF2C, JUNB, NEUROD1, TCF4, ZFP36, BATF, KLF4, ZFP69B, MED, EGR2, ELF3, ARID4B, RXR, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ZNF316, RUNX1-3, FOSL1, ZNF660, XBP1, HNF1A, ZNF101, SRSF4, PBX2, TSC22D4, ATF3, THRB, ZFP64, RUNX3, CBFB, TP63, MITF, BACH2, ZNF467, MAF, JMJD1C, MYOG, ELF1, SNAI2, KLF10, JUN, CTCF, TAF3, LMO1, MNT, DPF2, IRF4, TFAP2C, RBPJ, MLX, ZNF239, ZSCAN21, MTA2, ZBTB48, ZBTB17, ZNF317, SRF, NBN, CHD4, PBX1, TSHZ1, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, TERF2, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, SSRP1, NFIL3, THAP11, EZH2phosphoT487, LDB1, AFF4, SOX13, ZNF770, ARNT, DAXX, ZNF48, PRDM9, ZEB2, ETV6, PBX3, ZNF10, HMGXB4, TEAD3, ZXDB, ZNF680, U2AF1, KLF9, USF1, SP1, BCL11A, TFAP2A, ATF7, ASH2L, CTBP2, PRDM6, SMC3, MLLT1, STAG2, STAG1, ZNF394, AGO1, MTA3, EBF1, MEIS1, MAFF, ZNF580, BCL3, ZKSCAN1, KDM1A, ISL1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, ZNF768, TP53, ZNF334, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, TBX21, EGR1, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, TBX2, PGR, SOX2, PATZ1, LEO1, TFAP4, SIN3B, CHD7, MXD4, ZNF189, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, SRSF3, EZH2, ZNF652, SPI1, HDAC2, INTS13, ZNF490, ETV5, BCL6, SIN3A, ERG3, MEF2A, CREBBP, RARA, ZNF35, ZNF384, NFYC, HMGB2, ZNF518A, SMAD4, CDK8, ZEB1, SPDEF, ZMYM3, SUPT16H, NCOA1, SREBF2, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, FOXP1, AATF, NCOR2, PPARG, ZNF692, ZNF30, ZNF574, TCF7, RELA, TARDBP, SKIL, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, NEUROG2, PKNOX1, MYOD1, AR, PAX3-FOXO1, ZBTB16, YAP1, AHR, FOSL2, DMAP1, HMG20A, ZSCAN5C, E2F7, RBFOX2, ZNF28, SFMBT1, ZFHX2, LYL1, INSM2, NFIC, ZNF362, CTCFL, PRDM1, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, USF2, TCF12, EP300, BAF155, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, CDK7, MLLT3, GATAD1, ARID3A, ZNF300, ZNF585B, ASCL1, ZNF341, RAD21, GRHL3, PROX1, APC, ZNF614, XRCC5, ZNF639, ARNTL, ZNF750, FEZF1, TFE3, EHF, HBP1, IRF1, ZGPAT, ZNF766, MRTFB, PTBP1, SMC1A, MAFG, SIRT6, FIP1L1, ZFX, SMAD3, PCBP2, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, OSR2, GR, ZNF184, NRF1, PBX4, SUPT5H, FOS, CHD1, TGIF2, MED1, ZNF558, MYB, CEBPD, SCRT2, ZNF3, SETDB1, NIPBL, ZBTB7A, GLI2, POU2F3, PHIP, TCF3, SKI, ZNF283, FOXA2, RBBP5, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, BRCA1, SP140, HIF1A, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, ZNF843, BHLHE40, NFKBIZ, TAF1, ZBTB42, NOTCH3, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): CLIC6,SETD4,RUNX1,RCAN1,SMIM11A
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 48
  • Number of somatic mutations (non-coding): 12
  • Related genes and loops
  • Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216, ENSG00000185917,
  • Related loop: chr21:33950000-33975000~~chr21:34800000-34825000, chr21:34350000-34375000~~chr21:34800000-34825000, chr21:34350000-34375000~~chr21:34825000-34850000, chr21:34525000-34550000~~chr21:34800000-34825000, chr21:34675000-34700000~~chr21:34800000-34825000, chr21:34700000-34725000~~chr21:34825000-34850000, chr21:34725000-34750000~~chr21:34825000-34850000, chr21:34800000-34825000~~chr21:36025000-36050000, chr21:34825000-34850000~~chr21:36025000-36050000,
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