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Basic information

CohesinDB ID: CDBP00417880

Locus: chr21-34833081-34847342

Data sourse: GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR760NPX, GSE25021, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, ENCSR000EAC, GSE93080, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE135093, GSE120943, GSE206145-NatGen2015, GSE138105, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE116344, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, GSE38395, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE131956, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE73207

Cell type: MDM, RH4, GM2610, SLK, GM19240, OCI-AML-3, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, HeLa-S3, hLCL, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, SNYDER, Monocytes, MB157, TF-1, GM12878, GM12891, GM2588, GBM39, SK-N-SH, RT-112, THP-1, Macrophage, MCF-7, GM12892, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 49% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.478

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 24%, "7_Enh": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, KDM3A, HDGF, ZBTB44, ZNF586, TEAD1, SOX5, PAX8, DEK, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, ZNF263, TOP2A, BRD3, ZMYND11, STAT1, ZNF485, SAP130, ERG, ZBTB8A, SMARCA4, UBN1, RCOR1, NR2F6, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, FLI1, HCFC1, DRAP1, MXI1, RUNX1, CEBPA, SP5, SMARCC1, PRDM10, FOXM1, SMARCB1, NR1H2, C11orf30, MBD1, STAT5A, GSPT2, ARID2, IKZF5, ELL2, NFATC3, CBFA2T2, MEF2B, CBX3, CREM, CHD2, SS18, NFATC1, PAF1, WT1, MEF2C, JUNB, MAF1, PLAG1, KLF4, ZFP69B, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, NCOR1, ZNF316, FOSL1, ZNF660, XBP1, HNF1A, HNRNPK, ATF3, ZC3H8, THRB, RUNX3, MITF, ZNF467, JMJD1C, MAF, ELF1, RBM39, KLF10, CTCF, JUN, MNT, DPF2, TFAP2C, RBPJ, MLX, ZNF317, ZSCAN21, ZBTB48, CHD4, ONECUT1, HOMEZ, FOXP2, RXRA, BATF3, NKX3-1, PRDM14, MIER3, VDR, NR3C1, ESRRA, STAT5B, KMT2A, TBL1XR1, ZNF565, SSRP1, NFIL3, THAP11, SOX13, AFF4, ZNF770, ARNT, NFIB, DAXX, BACH1, ZNF48, PRDM9, PBX3, HMGXB4, TEAD3, U2AF1, USF1, BCL11A, SP1, ASH2L, CTBP2, PRDM6, ZNF623, SMC3, STAG1, MLLT1, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, CBX2, TP53, ZNF334, NFKB1, PHOX2B, PHF5A, BRD2, KAT8, TBX21, EGR1, RNF2, BRD4, JUND, PGR, FANCL, SOX2, LEO1, TFAP4, CHD7, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, TP73, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, KDM4C, ZSCAN5A, ERG2, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, GFI1, INO80, DNMT3B, EZH2, ZNF652, SPI1, PCBP1, HDAC2, ZNF490, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ERG3, MEF2A, RARA, NFYC, CREBBP, ZNF384, TAF15, HMGB2, SMAD4, CBFA2T3, CDK8, ZEB1, SPDEF, SUPT16H, NCOA1, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, FOXP1, PPARG, ZNF692, GTF2B, TCF7, RELA, TARDBP, MAX, NR2F1, TCF7L2, KDM5B, NEUROG2, ZNF547, MYOD1, T, AR, PAX3-FOXO1, ZNF324, DMAP1, AHR, FOSL2, HMG20A, E2F7, RBFOX2, ZFHX2, LYL1, NFIC, ZNF629, KLF5, TRIM28, ETV1, RCOR2, MLL, HNF1B, USF2, TCF12, BAF155, EP300, GATA6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, SRC, RUNX1T1, MLLT3, GATAD1, ARID3A, ZNF300, ZNF585B, ZNF341, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, TCF25, ARNTL, HBP1, TFE3, IRF1, ZGPAT, MRTFB, ZIM3, SMC1A, ZFX, SMAD3, PCBP2, TWIST1, RUNX2, CDK6, GATA4, ZNF184, GR, PBX4, NRF1, SUPT5H, FOS, CHD1, TGIF2, MED1, CEBPD, MYB, ZNF3, NIPBL, PHIP, TCF3, SKI, FOXA2, MIER2, ZNF600, ZBTB33, CDK9, HOXB13, YY1, BRCA1, SP140, HIF1A, GATA1, HAND2, CEBPG, NCOA3, NR2F2, BHLHE40, NFKBIZ, TAF1, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): RUNX1,CLIC6,SETD4,SMIM11A

Function elements

Human SNPs: Preeclampsia

Number of somatic mutations (coding): 1375

Number of somatic mutations (non-coding): 221

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159212, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00417880