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Basic information

CohesinDB ID: CDBP00417881

Locus: chr21-34847624-34848884

Data sourse: GSE67783, GSE86191, GSE138405, GSE111913, GSE206145, GSE206145-NatGen2015, GSE103477

Cell type: MDM, RPE, Hela-Kyoto, Fibroblast, HCT-116, RT-112, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 37%, "4_Tx": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NME2, FOXA1, MLL4, HDGF, MEN1, ZBTB44, ZNF322, IKZF3, PAX5, TEAD1, ZNF121, LMO2, ZNF561, ZNF577, E4F1, PAX8, DEK, ZNF528, KLF3, KMT2B, NANOG, POU5F1, ZNF263, BRD3, CTBP1, ZMYND11, STAT1, ZNF488, ERG, ZBTB21, PAX6, ZNF597, NFKB2, SMARCA4, FOXK2, UBN1, ZNF398, RCOR1, CEBPB, ZHX2, KLF17, GATA2, SIX2, FLI1, MXI1, RELB, RUNX1, CEBPA, HDAC1, CRY1, TRIM22, SMARCC1, PRDM10, ZNF549, ZXDC, ATF2, FOXM1, SP2, PIAS1, EVI1, STAT5A, ARID2, OVOL3, ELL2, NFATC3, MEF2B, ZNF207, CREM, CHD2, SS18, PAF1, ZSCAN16, WT1, MEF2C, JUNB, TCF4, ZFP36, BATF, SPIB, ZFP69B, KLF4, ZBTB6, EGR2, ELF3, EGLN2, ZNF366, HSF1, NCOR1, ZBTB26, SCRT1, FOSL1, ZNF660, XBP1, ZNF101, ATF3, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, ZNF467, MYOG, JMJD1C, MAF, ELF1, SNAI2, KLF10, CTCF, JUN, MNT, ZBTB20, DPF2, IRF4, ZNF280A, TFAP2C, RBPJ, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, ZNF317, NONO, DDX5, NBN, PHB2, CHD4, TSHZ1, ZNF2, LHX2, RXRA, BATF3, NKX3-1, PRDM14, TERF2, NR3C1, ESRRA, STAT5B, KMT2A, FOXK1, KLF8, ARHGAP35, GRHL2, ZKSCAN5, SSRP1, ZNF585A, ZBTB24, EZH2phosphoT487, AFF4, SOX13, POU4F2, ZNF770, ZNF513, ZNF18, SP3, ARNT, DAXX, BACH1, PRDM9, HMBOX1, ZEB2, ETV6, PBX3, ZNF10, ZXDB, KLF9, USF1, SP1, BCL11A, TFAP2A, ATF7, CTBP2, PRDM6, SMC3, STAG1, MLLT1, ZNF394, MTA3, EBF1, MAFF, ZNF580, KLF7, BCL3, KDM1A, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, TP53, NFKB1, ZSCAN22, PHOX2B, BRD2, TBX21, RB1, IKZF2, JUND, BRD4, ZSCAN23, PGR, PATZ1, LEO1, TFAP4, CHD7, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, SOX9, E2F6, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ZSCAN5A, ZMYND8, HIC1, SP4, ERG2, TBP, HOXC5, ETS1, MYC, NKX2-1, GABPA, STAT3, IKZF1, EZH2, SPI1, HDAC2, GATAD2B, ZNF76, ZNF554, NCOA2, BCL6, SIN3A, ZBTB12, ERG3, MEF2A, CREBBP, ZNF384, ZNF35, HMGB2, SMAD4, ZNF518A, CBFA2T3, CDK8, ZEB1, ZNF264, SUPT16H, NCOA1, ZNF22, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, BCOR, FOXP1, ZNF34, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, RELA, TARDBP, SKIL, MAX, GFI1B, NEUROG2, TCF7L2, KDM5B, NR2F1, MYOD1, T, AR, ZNF324, AHR, FOSL2, ZNF391, ZSCAN5C, E2F7, ZFHX2, LYL1, INSM2, NFIC, ZNF362, PRDM1, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, HNF1B, USF2, ZFP91, TCF12, EP300, BAF155, GATA6, PRDM4, RAD51, TEAD4, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, ID3, ARID3A, ASCL1, ZNF341, ZNF84, RAD21, GRHL3, PROX1, APC, ZNF639, ZNF750, FEZF1, TRPS1, EHF, IRF1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, SMAD3, RUNX2, GATA4, OSR2, ZNF184, GR, PBX4, NRF1, SUPT5H, FOS, CHD1, MED1, MYB, SCRT2, L3MBTL2, KLF16, NIPBL, GLI2, PHIP, TCF3, SKI, NELFA, FOXA2, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, YY1, HIF1A, OTX2, ZNF449, TLE3, SP7, NCOA3, NR2F2, ZNF687, ZNF213, ZNF843, BHLHE40, TAF1, ZBTB42, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): CLIC6,SETD4,SMIM11A,RUNX1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 30

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159212, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00417881