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Basic information

CohesinDB ID: CDBP00417882

Locus: chr21-34849980-34869247

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, GSE126634, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, GSE25021, ENCSR917QNE, GSE165895, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, GSE135093, GSE152721, GSE120943, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR703TNG, GSE116344, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, GSE85526, ENCSR000ECE, ENCSR981FDC, ENCSR000BMY, GSE62063, GSE97394, GSE55407, ENCSR000BTQ, GSE38395, ENCSR167MTG, ENCSR853VWZ, GSE110061, GSE129526, ENCSR000HPG, GSE111913, GSE155324, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE64758

Cell type: MDM, RH4, GM10847, GM2610, GM19240, OCI-AML-3, HSPC, Liver, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GM19239, HeLa-Tet-On, RT-112, THP-1, Macrophage, HUES64, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HCAEC, GM19238, Neutrophil, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 35% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.400

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 28%, "5_TxWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: TRIM25, CBFA2T2, ZNF316, ZSCAN5D, MYCN, SS18, ZFX, POU4F2, XBP1, ZBTB48, WT1, ZSCAN5A, FOXA1, ZNF81, ZNF823, LEO1, ZNF18, ERG, RELA, CREBBP, ATF3, MYC, RAD21, SP140, GRHL3, ARNT, SUPT5H, AGO2, ZNF143, HNRNPH1, KMT2A, RBM39, SNAI2, ZNF3, ESR1, PKNOX1, ZNF334, USF2, MYOD1, CTCF, RBM22, ARRB1, BHLHE40, AR, FLI1, CLOCK, MAZ, SMC3, STAG1, AHR

Target gene symbol (double-evidenced CRMs): CLIC6,SMIM11A,RCAN1,SETD4,RUNX1

Function elements

Human SNPs: Eosinophil_counts

Number of somatic mutations (coding): 1825

Number of somatic mutations (non-coding): 335

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216, ENSG00000185917,

eachgene

Deatailed information for cohesin site CDBP00417882