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Basic information

CohesinDB ID: CDBP00417883

Locus: chr21-34870048-34873238

Data sourse: GSE67783, GSE86191, GSE111913, ENCSR000HPG, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE68388, GSE83726, GSE103477, GSE116344, GSE131606

Cell type: MDM, RPE, Fibroblast, HCT-116, RH4, RT-112, IMR-90, K-562, HSPC, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.889

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 37%, "5_TxWk": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, PGR, SOX2, NME2, XBP1, FOXA1, RBFOX2, PBX2, LEO1, HDGF, MEN1, THRB, ZC3H8, RUNX3, PRDM1, ZNF429, ATF4, ZNF189, PAX5, TP63, ZSCAN4, ZNF736, JMJD1C, MAF, TEAD1, ELF1, ZNF121, KLF6, BCLAF1, NFE2L2, LMO2, ESR1, SMAD5, USF2, CTCF, BAF155, DPF2, SIX5, IRF4, TRIM24, RAD51, KMT2B, PDX1, TFAP2C, EED, RBPJ, POU2F2, BRD1, MYCN, POU5F1, RUNX1T1, ID3, TOP2A, MTA2, ZBTB48, ZSCAN5A, STAT1, ERG2, ARID3A, ZNF300, HOXC5, ERG, PBX1, ASCL1, OGG1, MYC, SMARCA4, RAD21, GRHL3, NKX2-1, STAT3, XRCC5, PRDM14, RCOR1, TERF2, CD74, VDR, ARNTL, NR3C1, ESRRA, CEBPB, KMT2A, EZH2, GRHL2, SPI1, ZNF257, GATA2, SIX2, FLI1, ZIM3, CEBPA, SIRT6, ZFX, ZNF534, SMAD3, ZNF770, ERG3, ZNF549, ZNF384, GATA4, DAXX, PBX4, ZNF48, PRDM9, SMAD4, ETV6, PBX3, SUPT5H, CHD1, SNRNP70, CDK8, FOS, MED1, TERF1, PML, MYB, SCRT2, RBM22, TFAP2A, ARID2, REST, POU2F3, ATF7, ASH2L, HNRNPLL, HOXA9, PHIP, TCF3, FOXP1, BCOR, SMC3, STAG1, MLLT1, SKI, PPARG, TBL1X, FOXA2, EBF1, MEIS1, SS18, CREM, GTF2B, WT1, ESR2, FOXF1, ZBTB33, ZNF823, CDK9, HOXB13, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, JUNB, SP140, TCF4, HIF1A, BHLHE22, GATA3, BATF, TAL1, MAX, GATA1, AGO2, ZNF143, PLAG1, ZFP69B, NR2F2, NR2F1, TCF7L2, TP53, PKNOX1, MED, ZNF334, NFKB1, MYOD1, ELF3, AR, TAF1, ZBTB40, HSF1, IKZF2, BRD4, SCRT1, MAZ, AHR

Target gene symbol (double-evidenced CRMs): RUNX1,CLIC6,SETD4,SMIM11A,RCAN1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 60

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216, ENSG00000185917,

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Deatailed information for cohesin site CDBP00417883