Browse_each

Basic information

CohesinDB ID: CDBP00417885

Locus: chr21-34876603-34893358

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE168045, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, T-47D, GM12878, TC-71, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, SC, A-549, HUVEC, HCAEC, Ramos, GM19238, CNCC-WT33iPSC, BGO3, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 88% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.144

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "2_TssAFlnk": 16%, "1_TssA": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, PGR, SOX2, NME2, XBP1, FOXA1, RBFOX2, PBX2, LEO1, HDGF, MEN1, THRB, ZC3H8, RUNX3, PRDM1, ZNF429, ATF4, ZNF189, PAX5, TP63, ZSCAN4, ZNF736, JMJD1C, MAF, TEAD1, ELF1, ZNF121, KLF6, BCLAF1, NFE2L2, LMO2, ESR1, SMAD5, USF2, CTCF, BAF155, DPF2, SIX5, IRF4, TRIM24, RAD51, KMT2B, PDX1, TFAP2C, EED, RBPJ, POU2F2, BRD1, MYCN, POU5F1, RUNX1T1, ID3, TOP2A, MTA2, ZBTB48, ZSCAN5A, STAT1, ERG2, ARID3A, ZNF300, HOXC5, ERG, PBX1, ASCL1, OGG1, MYC, SMARCA4, RAD21, GRHL3, NKX2-1, STAT3, XRCC5, PRDM14, RCOR1, TERF2, CD74, VDR, ARNTL, NR3C1, ESRRA, CEBPB, KMT2A, EZH2, GRHL2, SPI1, ZNF257, GATA2, SIX2, FLI1, ZIM3, CEBPA, SIRT6, ZFX, ZNF534, SMAD3, ZNF770, ERG3, ZNF549, ZNF384, GATA4, DAXX, PBX4, ZNF48, PRDM9, SMAD4, ETV6, PBX3, SUPT5H, CHD1, SNRNP70, CDK8, FOS, MED1, TERF1, PML, MYB, SCRT2, RBM22, TFAP2A, ARID2, REST, POU2F3, ATF7, ASH2L, HNRNPLL, HOXA9, PHIP, TCF3, FOXP1, BCOR, SMC3, STAG1, MLLT1, SKI, PPARG, TBL1X, FOXA2, EBF1, MEIS1, SS18, CREM, GTF2B, WT1, ESR2, FOXF1, ZBTB33, ZNF823, CDK9, HOXB13, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, JUNB, SP140, TCF4, HIF1A, BHLHE22, GATA3, BATF, TAL1, MAX, GATA1, AGO2, ZNF143, PLAG1, ZFP69B, NR2F2, NR2F1, TCF7L2, TP53, PKNOX1, MED, ZNF334, NFKB1, MYOD1, ELF3, AR, TAF1, ZBTB40, HSF1, IKZF2, BRD4, SCRT1, MAZ, AHR

Target gene symbol (double-evidenced CRMs): SETD4,RUNX1,RCAN1,AP000311.1,SIM2,ITSN1,SMIM11A,CLIC6,ATP5PO

Function elements

Human SNPs: Platelet_count

Number of somatic mutations (coding): 4556

Number of somatic mutations (non-coding): 682

Related genes and loops

Related gene: ENSG00000249209, ENSG00000205726, ENSG00000241837, ENSG00000205670, ENSG00000159200, ENSG00000159212, ENSG00000159216, ENSG00000185917, ENSG00000159263,

eachgene

Deatailed information for cohesin site CDBP00417885