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Basic information

CohesinDB ID: CDBP00417890

Locus: chr21-34901155-34901514

Data sourse: GSE206145, GSE206145-NatGen2015, GSE67783, GSE86191

Cell type: RPE, Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 50%, "14_ReprPCWk": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, PAX7, FOSL1, EZH2phosphoT487, BRD3, SOX2, XBP1, GTF2B, DUX4, SMAD3, ZBTB48, WT1, ZBTB33, MEF2C, CDK9, HOXB13, HOXC5, KDM1A, ERG, RELA, MYC, RUNX2, ZBTB44, PBX4, DAXX, PROX1, RXRA, CBFB, APC, MAX, STAT3, SUPT5H, CDK8, GATA1, MED1, CDX2, JMJD1C, CEBPB, TEAD3, TRIM28, KMT2A, ZNF121, ZMYM3, MYB, TP53, ESR1, TP73, CTCF, SPI1, HNF4A, AR, RBM25, HOXA9, JUND, BRD4, ZNF24, MLLT1

Target gene symbol (double-evidenced CRMs): RUNX1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 2

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159216,

eachgene

Deatailed information for cohesin site CDBP00417890