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Basic information

CohesinDB ID: CDBP00417891

Locus: chr21-34903345-34903867

Data sourse: GSE62063, ENCSR879KXD

Cell type: K-562, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: NIPBL,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 51%, "14_ReprPCWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, HLF, RXRB, KDM3A, HDGF, MEN1, PAX5, TEAD1, E2F5, LMO2, E4F1, ZNF75A, SOX5, PYGO2, PAX8, DEK, ZNF410, KMT2B, GATAD2A, POU5F1, HHEX, TOP2A, ZNF263, CTBP1, STAT1, SAP130, ERG, EZH1, SMARCA4, RFX1, FOXK2, ZNF197, RCOR1, NR2F6, NFRKB, DACH1, CEBPB, HNRNPL, CREB1, GABPB1, ELF4, ZHX2, MIXL1, GATA2, ZNF644, MXD3, FLI1, DRAP1, NR2C2, HCFC1, MXI1, EP400, RUNX1, HDAC1, CEBPA, TBX3, SP5, SMARCC1, PRDM10, ZBTB2, ELK1, TFDP1, ATF2, FOXM1, FOXJ2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, STAT5A, IKZF5, RBM25, AFF1, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, CBX3, CREM, CHD2, WT1, MEF2C, CREB3L1, JUNB, NEUROD1, TCF4, ZFP36, BATF, SPIB, PLAG1, KLF4, BCL11B, ZKSCAN8, MED, ELF3, ARID4B, RXR, ZBTB26, NCOR1, HSF1, ILF3, ADNP, ZNF316, FOSL1, XBP1, HNF1A, KDM4B, PBX2, TSC22D4, ATF3, ZFP64, RUNX3, CBFB, MITF, CDC5L, JMJD1C, INTS11, MYOG, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, L3MBTL4, MNT, LMO1, DPF2, DDX20, TFAP2C, RBPJ, MLX, MTA2, ZNF317, ZBTB17, ZBTB48, NONO, SRF, NBN, PHB2, PBX1, TRIP13, HOMEZ, RXRA, PRDM14, MIER3, LEF1, VDR, NR3C1, ESRRA, KMT2A, ZBTB11, TBL1XR1, GRHL2, SMARCA5, NFIL3, CC2D1A, THAP11, LDB1, EZH2phosphoT487, SOX13, AFF4, ZMIZ1, ZNF18, ARNT, BACH1, DAXX, ZNF48, PRDM9, HMBOX1, ZEB2, ETV6, HMGXB4, TEAD3, DIDO1, TAF7, USF1, BCL11A, SP1, TFAP2A, ATF7, ASH2L, SMC3, STAT2, MLLT1, STAG2, STAG1, MTA3, EBF1, MEIS1, MAFF, ZNF580, ZKSCAN1, KDM1A, GATA3, TAL1, NRIP1, ZNF143, MTA1, ZNF334, PHF5A, KAT8, TBX21, EGR1, RNF2, BRD4, JUND, CUX1, SMAD4.1D12, IRF9, PGR, ZNF496, SOX2, LEO1, UBTF, TFAP4, ATF4, MXD4, SMARCE1, RLF, KLF6, MCM7, NFE2L2, ZNF217, ESR1, KLF1, E2F6, TRIM24, GTF2F1, POU2F2, ERG2, TBP, HNF4G, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, EZH2, SPI1, HDAC2, INTS13, GATAD2B, TAF9B, ZNF490, NCOA2, ETV5, BCL6, SIN3A, NFXL1, ERG3, MEF2A, MYBL2, RARA, ZNF384, NFYC, CREBBP, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, NCOA1, ZNF22, MAFK, NR4A1, HNF4A, REST, BCOR, FOXP1, ILK, PTTG1, PPARG, JDP2, TCF7, ZNF318, FOXO3, RELA, TARDBP, CHAMP1, ZNF282, SKIL, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, MYOD1, T, AR, PAX3-FOXO1, ZBTB16, ZNF395, DMAP1, FOSL2, AHR, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, LYL1, ZNF274, NFIC, PRDM1, MECOM, HDAC3, CDX2, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, USF2, ZFP91, TCF12, EP300, GATA6, CREB3, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, MYCN, CDK7, ID3, RUNX1T1, ZNF205, MLLT3, GATAD1, ARID3A, MIER1, EOMES, RAD21, GRHL3, ZNF614, XRCC5, NFE2, ZNF639, HES1, TFE3, EHF, ZSCAN2, IRF1, ZGPAT, ZNF766, HEXIM1-CDK9, ZC3H11A, ATF1, PTBP1, MAFG, SMC1A, CBX1, SIRT6, ZFX, SMAD3, CBX8, IRF2, NCOA6, NOTCH1, BRD9, RUNX2, GATA4, ZNF184, PBX4, NR2C1, SUPT5H, FOS, TGIF2, MED1, CEBPD, MYB, VEZF1, ZNF3, L3MBTL2, KLF16, NIPBL, ZBTB7A, CCNT2, POU2F3, TCF3, SKI, KLF13, FOXA2, E2F8, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, HIF1A, BHLHE22, GATA1, CEBPG, NCOA3, NR2F2, ZNF83, ZNF512, NFKBIZ, BHLHE40, TAF1, ZBTB40, MYNN, CLOCK, MAZ, MEF2D, ZNF24

Target gene symbol (double-evidenced CRMs): RUNX1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 4

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000159216,

eachgene

Deatailed information for cohesin site CDBP00417891