- Basic information
- CohesinDB ID: CDBP00417895
- Locus: chr21-34911237-34917573
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000BSB, ENCSR501LQA, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, GSE165895, ENCSR000EFJ, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, GSE112028, GSE138105, ENCSR703TNG, GSE116344, GSE94872, ENCSR000EEG, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR495WGO, GSE97394, GSE55407, ENCSR000BTQ, ENCSR167MTG, GSE129526, GSE111913, ENCSR335RKQ, ENCSR000EDE, ENCSR153HNT, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS
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Cell type: MDM, RH4, GM10847, GM2610, SLK, GM19240, OCI-AML-3, HSPC, H9-hESC, RPE, GM2630, HMEC, Fibroblast, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, H1-hESC, SNYDER, Monocytes, GM18505, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, THP-1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, GM19238, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 32% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.456
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 27%,
"15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, HLF, RXRB, KDM3A, HDGF, MEN1, PAX5, TEAD1, E2F5, LMO2, E4F1, ZNF75A, SOX5, PYGO2, PAX8, DEK, ZNF410, KMT2B, GATAD2A, POU5F1, HHEX, TOP2A, ZNF263, CTBP1, STAT1, SAP130, ERG, EZH1, SMARCA4, RFX1, FOXK2, ZNF197, RCOR1, NR2F6, NFRKB, DACH1, CEBPB, HNRNPL, CREB1, GABPB1, ELF4, ZHX2, MIXL1, GATA2, ZNF644, MXD3, FLI1, DRAP1, NR2C2, HCFC1, MXI1, EP400, RUNX1, HDAC1, CEBPA, TBX3, SP5, SMARCC1, PRDM10, ZBTB2, ELK1, TFDP1, ATF2, FOXM1, FOXJ2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, STAT5A, IKZF5, RBM25, AFF1, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, CBX3, CREM, CHD2, WT1, MEF2C, CREB3L1, JUNB, NEUROD1, TCF4, ZFP36, BATF, SPIB, PLAG1, KLF4, BCL11B, ZKSCAN8, MED, ELF3, ARID4B, RXR, ZBTB26, NCOR1, HSF1, ILF3, ADNP, ZNF316, FOSL1, XBP1, HNF1A, KDM4B, PBX2, TSC22D4, ATF3, ZFP64, RUNX3, CBFB, MITF, CDC5L, JMJD1C, INTS11, MYOG, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, L3MBTL4, MNT, LMO1, DPF2, DDX20, TFAP2C, RBPJ, MLX, MTA2, ZNF317, ZBTB17, ZBTB48, NONO, SRF, NBN, PHB2, PBX1, TRIP13, HOMEZ, RXRA, PRDM14, MIER3, LEF1, VDR, NR3C1, ESRRA, KMT2A, ZBTB11, TBL1XR1, GRHL2, SMARCA5, NFIL3, CC2D1A, THAP11, LDB1, EZH2phosphoT487, SOX13, AFF4, ZMIZ1, ZNF18, ARNT, BACH1, DAXX, ZNF48, PRDM9, HMBOX1, ZEB2, ETV6, HMGXB4, TEAD3, DIDO1, TAF7, USF1, BCL11A, SP1, TFAP2A, ATF7, ASH2L, SMC3, STAT2, MLLT1, STAG2, STAG1, MTA3, EBF1, MEIS1, MAFF, ZNF580, ZKSCAN1, KDM1A, GATA3, TAL1, NRIP1, ZNF143, MTA1, ZNF334, PHF5A, KAT8, TBX21, EGR1, RNF2, BRD4, JUND, CUX1, SMAD4.1D12, IRF9, PGR, ZNF496, SOX2, LEO1, UBTF, TFAP4, ATF4, MXD4, SMARCE1, RLF, KLF6, MCM7, NFE2L2, ZNF217, ESR1, KLF1, E2F6, TRIM24, GTF2F1, POU2F2, ERG2, TBP, HNF4G, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, EZH2, SPI1, HDAC2, INTS13, GATAD2B, TAF9B, ZNF490, NCOA2, ETV5, BCL6, SIN3A, NFXL1, ERG3, MEF2A, MYBL2, RARA, ZNF384, NFYC, CREBBP, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, NCOA1, ZNF22, MAFK, NR4A1, HNF4A, REST, BCOR, FOXP1, ILK, PTTG1, PPARG, JDP2, TCF7, ZNF318, FOXO3, RELA, TARDBP, CHAMP1, ZNF282, SKIL, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, MYOD1, T, AR, PAX3-FOXO1, ZBTB16, ZNF395, DMAP1, FOSL2, AHR, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, LYL1, ZNF274, NFIC, PRDM1, MECOM, HDAC3, CDX2, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, USF2, ZFP91, TCF12, EP300, GATA6, CREB3, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, MYCN, CDK7, ID3, RUNX1T1, ZNF205, MLLT3, GATAD1, ARID3A, MIER1, EOMES, RAD21, GRHL3, ZNF614, XRCC5, NFE2, ZNF639, HES1, TFE3, EHF, ZSCAN2, IRF1, ZGPAT, ZNF766, HEXIM1-CDK9, ZC3H11A, ATF1, PTBP1, MAFG, SMC1A, CBX1, SIRT6, ZFX, SMAD3, CBX8, IRF2, NCOA6, NOTCH1, BRD9, RUNX2, GATA4, ZNF184, PBX4, NR2C1, SUPT5H, FOS, TGIF2, MED1, CEBPD, MYB, VEZF1, ZNF3, L3MBTL2, KLF16, NIPBL, ZBTB7A, CCNT2, POU2F3, TCF3, SKI, KLF13, FOXA2, E2F8, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, HIF1A, BHLHE22, GATA1, CEBPG, NCOA3, NR2F2, ZNF83, ZNF512, NFKBIZ, BHLHE40, TAF1, ZBTB40, MYNN, CLOCK, MAZ, MEF2D, ZNF24
- Target gene symbol (double-evidenced CRMs): RUNX1
- Function elements
- Human SNPs: Eosinophil_percentage_of_granulocytes
- Number of somatic mutations (coding): 54
- Number of somatic mutations (non-coding): 0
- Related genes and loops