- Basic information
- CohesinDB ID: CDBP00417899
- Locus: chr21-34926745-34927644
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Data sourse: ENCSR167MTG, ENCSR230ZWH, GSE72082, GSE98367, ENCSR000BLY, ENCSR879KXD, ENCSR000BLS, GSE206145-NatGen2015, ENCSR054FKH, GSE120943, GSE68388, GSE103477, GSE25021, ENCSR000EDW, ENCSR917QNE
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Cell type: Macrophage, Fibroblast, Monocytes, Hep-G2, SK-N-SH, K-562, Liver, THP-1, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 6% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.900
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: False
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 38%,
"7_Enh": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, HMG20A, RXRB, UBTF, PBX2, KDM3A, ATF3, NFIC, RUNX3, PRDM1, ATF4, CBFB, CDX2, TEAD1, ZNF121, TRIM28, NFE2L2, RCOR2, TP73, CTCF, TCF12, EP300, SOX5, PAX8, DMAP1, IRF4, TEAD4, FOXA3, ZNF175, GATAD2A, RBPJ, DUX4, STAT1, MLLT3, DDX5, SAP130, TBP, HNF4G, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, PROX1, NKX2-1, BATF3, XRCC5, ZNF614, IKZF1, RCOR1, NFE2, NR2F6, CEBPB, KMT2A, EZH2, GRHL2, ZNF652, GABPB1, ZNF436, SPI1, MIXL1, ZNF257, HDAC2, GATA2, ZNF644, DRAP1, ZGPAT, ZNF766, NFIL3, ETV5, RUNX1, THAP11, MAFG, BCL6, CEBPA, NKX2-2, SOX13, ZFX, PRDM10, RARA, ZNF384, RUNX2, GATA4, DAXX, BACH1, NRF1, ZNF48, SMAD4, HMBOX1, PBX3, MAFB, SUPT5H, CDK8, MED1, TEAD3, NR1H2, C11orf30, MAFK, SP1, BCL11A, NR4A1, HNF4A, REST, POU2F3, ASH2L, PHIP, STAG1, PPARG, FOXA2, MIER2, MAFF, ZBTB33, MEF2C, ZNF580, KDM1A, RELA, AHR, HIF1A, GATA3, BATF, MAX, ZNF143, GATA1, HAND2, CEBPG, GFI1B, NR2F2, TP53, MED, ZNF334, PHOX2B, ELF3, BRD2, KAT8, ARID4B, AR, NFKBIZ, NCOR1, JUND, BRD4, ZNF316, FOSL2
- Target gene symbol (double-evidenced CRMs): RUNX1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 2
- Number of somatic mutations (non-coding): 0
- Related genes and loops