- Basic information
- CohesinDB ID: CDBP00417917
- Locus: chr21-34959649-34961568
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Data sourse: GSE143937, GSE67783, ENCSR000BKV, ENCSR000FAD, GSE72082, GSE98367, ENCSR000EGW, ENCSR879KXD, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE108869, GSE126755
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Cell type: RPE, Fibroblast, Hep-G2, HeLa-S3, K-562, Neutrophil, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 36%,
"5_TxWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, NANOG, CEBPA, ZNF263, MYCN, CRY1, FOXA2, ZFX, CTBP1, ZNF317, POU5F1, ZBTB48, WT1, STAT1, FOXA1, ZSCAN5A, SOX2, LEO1, HOXB13, YY1, RELA, TARDBP, SMARCA4, RAD21, SP140, ZIC2, GRHL3, CHD7, HMBOX1, GATA1, IKZF1, RCOR1, MITF, DACH1, NR2F6, PLAG1, CBX2, CEBPG, CEBPB, GFI1B, TERF1, TRIM28, NR2F1, NFE2L2, PIAS1, ESR1, TP53, MYOD1, CTCF, BCL11A, BAF155, AR, ARID2, REST, GATA2, FLI1, NCOR1, BRD4, JUND, FOXP1, MAZ, SMC3, STAG1
- Target gene symbol (double-evidenced CRMs): RUNX1,SMIM11A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 18
- Number of somatic mutations (non-coding): 0
- Related genes and loops